[(1S,2S,3R)-2-Benzyloxymethyl-3-((S)-1-methylcarbamoyl-2-phenyl-ethylcarbamoyl)-cyclopropylmethoxy]-acetic acid tert-butyl ester

Base Information

Chemical Name:[(1S,2S,3R)-2-Benzyloxymethyl-3-((S)-1-methylcarbamoyl-2-phenyl-ethylcarbamoyl)-cyclopropylmethoxy]-acetic acid tert-butyl ester
CAS No.:201553-46-0
Molecular Formula:C₂₉H₃₈N₂O₆
Molecular Weight:510.631
Hs Code.:

Synonyms:[(1S,2S,3R)-2-Benzyloxymethyl-3-((S)-1-methylcarbamoyl-2-phenyl-ethylcarbamoyl)-cyclopropylmethoxy]-acetic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [(1S,2S,3R)-2-Benzyloxymethyl-3-((S)-1-methylcarbamoyl-2-phenyl-ethylcarbamoyl)-cyclopropylmethoxy]-acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of [(1S,2S,3R)-2-Benzyloxymethyl-3-((S)-1-methylcarbamoyl-2-phenyl-ethylcarbamoyl)-cyclopropylmethoxy]-acetic acid tert-butyl ester

There total 7 articles about [(1S,2S,3R)-2-Benzyloxymethyl-3-((S)-1-methylcarbamoyl-2-phenyl-ethylcarbamoyl)-cyclopropylmethoxy]-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 201553-44-8
(1S,2S,3S)-2-Benzyloxymethyl-3-hydroxymethyl-cyclopropanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide

: 201553-46-0
[(1S,2S,3R)-2-Benzyloxymethyl-3-((S)-1-methylcarbamoyl-2-phenyl-ethylcarbamoyl)-cyclopropylmethoxy]-acetic acid tert-butyl ester

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 14h;
DOI:10.1016/S0960-894X(97)10171-8

Reference yield:

: 35373-92-3
L-phenylalanine methylamide

: 201553-46-0
[(1S,2S,3R)-2-Benzyloxymethyl-3-((S)-1-methylcarbamoyl-2-phenyl-ethylcarbamoyl)-cyclopropylmethoxy]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / 2-hydroxypyridine / toluene / 48 h / Heating

2: 56 percent / NaH, Bu₄NI / dimethylformamide / 14 h / 0 - 20 °C

With 2-hydroxypyridin; tetra-(n-butyl)ammonium iodide; sodium hydride; In N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0960-894X(97)10171-8

Reference yield:

: 100-39-0
benzyl bromide

: 201553-46-0
[(1S,2S,3R)-2-Benzyloxymethyl-3-((S)-1-methylcarbamoyl-2-phenyl-ethylcarbamoyl)-cyclopropylmethoxy]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / NaH, Bu₄NI / dimethylformamide / 4 h / 0 °C

2: 59 percent / 2-hydroxypyridine / toluene / 48 h / Heating

3: 56 percent / NaH, Bu₄NI / dimethylformamide / 14 h / 0 - 20 °C

With 2-hydroxypyridin; tetra-(n-butyl)ammonium iodide; sodium hydride; In N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0960-894X(97)10171-8