33687-74-0

Upstream product

• 79-46-9 2-nitropropane 
• 100-52-7 benzaldehyde 
• 5447-97-2 2-bromo-2-nitropropane 
• 100-39-0 benzyl bromide 
• 69119-37-5 2-aci-nitropropane (t-butyl)dimethylsilyl ester 

Downstream Products

• 29329-26-8 2,2-dimethyl-2-nitro-1-phenyl-1-ethanone 
• 34405-41-9 α-(1-Methyl-1-nitroethyl)-benzylchlorid 
• 68385-34-2 N-(2-hydroxy-1,1-dimethyl-2-phenylethyl)hydroxylamine 
• 34405-42-0 α-(1-amino-1-methylethyl)benzenemethanol 
• 79-46-9 2-nitropropane 
• 100-52-7 benzaldehyde 
• 72949-59-8 1-Bromo-2-methyl-2-nitro-1-phenylpropan 
• 65-85-0 benzoic acid 
• 611-70-1 phenyl isopropyl ketone 
• 180081-15-6 tert-butyl N-[2-methyl-1-(4-nitrophenyl)-2-propyl]carbamate 
• 82408-64-8 N-(1,1-dimethyl-2-(4-nitrophenyl)ethyl)amine 
• 122-09-8 Phentermin 
• 1198312-18-3 C₂₁H₂₉N₃O₄S 
• 1198312-16-1 C₂₁H₂₇N₃O₆S 

Relevant academic research and scientific papers

Novel synthetic approach to 1α,24(R)-dihydroxyvitamin D3 using an asymmetric nitroaldol reaction

Rare earth-K-(S)-BINOL complexes were used to catalyze the nitroaldol reaction of the CD-ring 24-aldehyde precursors with 2-nitropropane in a good stereoselective manner. The obtained nitroaldol compound was easily converted into a synthetic intermediate

Copper complexes of 1,4-diazabutadiene ligands: Tuning of metal oxidation state and, application in catalytic C-C and C-N bond formation

Reaction of 1,4-diazabutadiene (p-RC6H4N = C(H)(H)C = NC6H4R-p; R = OCH3, CH3, H and Cl; abbreviated as L-R) with CuCl2·2H2O in methanol at ambient temperature (25 °C) affords a group of doubly chloro-bridged dicopper complexes of type [{CuI(L-R)Cl}2], designated as 1-R. Similar reaction carried out in acetonitrile furnishes a family of doubly chloro-bridged dicopper complexes of type [{CuII(L-R)Cl2}2], designated as 2-R. Molecular structures of 1-OCH3 and 2-OCH3 have been determined by X-ray crystallography. While copper(I) is having a nearly tetrahedral N2Cl2 coordination sphere in 1-OCH3, the N2Cl3 coordination sphere around copper(II) is distorted square pyramidal in nature in 2-OCH3. Isolated 2-R complexes, on dissolution in methanol, are found to undergo facile reduction of the metal center to generate the corresponding 1-R complexes. The 1-R and 2-R complexes show intense absorptions in the visible and ultraviolet regions. Cyclic voltammetry on the 1-R and 2-R complexes shows both metal-centered and ligand centered redox responses. The 1-R complexes are found to efficiently catalyze C-N cross-coupling reactions between arylboronic acids and aryl amines; while the 2-R complexes display notable catalytic efficiency for nitroaldol reactions.

Benzenesulfonyl-Asymmetric Ureas and Medical Uses Thereof

Benzenesulfonyl-asymmetric ureas are provided for the treatment of conditions modulated by the ghrelin receptor.

Preparation of indium nitronates and their Henry reactions

Indium nitronates were readily prepared from commercially available nitroalkanes by transmetallation of the corresponding lithium nitronates with indium salts. The Henry reaction of this indium organometallics with aldehydes afforded β-nitroalkanols in moderate to high yields. The use of chiral sugar aldehydes furnished the corresponding carbohydrate-derived β-nitroalkanols with excellent stereoselectivity.

Indium-mediated reaction of 1-bromo-1-nitroalkanes with aldehydes: Access to 2-nitroalkan-1-ols

A novel method for the preparation of 2-nitroalkan-1-ols by an indium-promoted reaction of bromonitromethane with a variety of aldehydes is reported. The reaction was also performed with 2-bromo-2-nitropropanes to afford 2,2-dialkyl-2-nitroalkan-1-ols. The use of chiral sugar-derived aldehydes furnished the corresponding 2-nitroalkan-1-ols with excellent stereoselectivity. The utility of the novel sugar-derived 2,2-dialkyl-2-nitroalkan-1-ols for the preparation of branched iminosugar derivatives was demonstrated by the preparation of a hydroxymethyl branched polyhydroxylated azepane.

INDOZALYL SULPHONAMIDE DERIVATIVES USEFUL AS GLUCOCORTICOID MODULATORS

Compounds of formula (I) or a pharmaceutically acceptable salt thereof; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating the glucocorticoid receptor in a warm blooded animal).

Henry reaction and 1,4-addition of nitroalkanes to α,β- unsaturated carbonyl compounds under the influence of MS 4 A in DMSO

In the presence of MS 4 A in DMSO (dimethyl sulfoxide), Henry reaction with various carbonyl compounds and nitroalkanes proceeded smoothly to give the corresponding β-nitroalcohol without a base catalyst. Moreover, 1,4-additon of nitroalkane to α,β-unsaturated ketones was also performed in DMSO. Copyright

Tandem Hass-Bender/Henry reaction for the synthesis of dimethylnitro alcohols from benzylic halides

Dimethylnitro alcohols are constructed in a one-pot process from benzylic halides and 2-nitropropane. The use of tetrabutylammonium fluoride (TBAF) as the promoter is essential for this tandem Hass-Bender/Henry reaction to proceed.

Generation and reaction of alkene radical cations under nonoxidizing conditions: Synthesis of the pyrrolizidine nucleus

(equation presented) Stable β-phosphatoxy nitroalkanes, readily assembled by the Henry reaction and subsequent phosphorylation, serve as good precursors to alkene radical cations on treatment with triphenyltin or tributyl hydride and AIBN in benzene at re

P(RNCH2CH2)3N: An Efficient Promoter for the Nitroaldol (Henry) Reaction

The use of catalytic amounts of the proazaphosphatranes P(MeNCH2CH2)3N, P(i-PrNCH2CH2)3N and P(HNCH2CH2)(i-PrNCH2CH2) 2N as nonionic bases in the reaction of nitroalkanes with carbonyl compounds is reported. The reaction proceeds at room temperature in the presence of 2.2 equiv of magnesium sulfate to produce the corresponding β-nitroalkanols in generally superior yields. Aldehydes react quantitatively in 5-60 min, whereas ketones require up to 3 h to react with nitromethane and up to 7 h for the reaction of ketones with higher nitroalkanes.