6-bromo-2-[(4-chlorophenylsulfonyl)methyl]-3-nitroimidazo[1,2-a]pyridine

Base Information

• Chemical Name: 6-bromo-2-[(4-chlorophenylsulfonyl)methyl]-3-nitroimidazo[1,2-a]pyridine
• CAS No.: 913530-53-7
• Molecular Formula: C₁₄H₉BrClN₃O₄S
• Molecular Weight: 430.666
• Mol file: 913530-53-7.mol

Synonyms:6-bromo-2-[(4-chlorophenylsulfonyl)methyl]-3-nitroimidazo[1,2-a]pyridine

Chemical Property of 6-bromo-2-[(4-chlorophenylsulfonyl)methyl]-3-nitroimidazo[1,2-a]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-bromo-2-[(4-chlorophenylsulfonyl)methyl]-3-nitroimidazo[1,2-a]pyridine

There total 4 articles about 6-bromo-2-[(4-chlorophenylsulfonyl)methyl]-3-nitroimidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

6-bromo-2-(chloromethyl)-3-nitro-1H-imdiazo[1,2-a]pyridine + sodium p-chlorobenzenesulphinate (14752-66-0) → 6-bromo-2-[(4-chlorophenylsulfonyl)methyl]-3-nitroimidazo[1,2-a]pyridine (913530-53-7)

Guidance literature:

In dimethyl sulfoxide; at 20 ℃; for 3h; Irradiation;

DOI:10.1007/s10870-007-9256-z

Reference yield: 60.0%

6-bromo-2-(chloromethyl)-3-nitro-1H-imdiazo[1,2-a]pyridine + 4-chlorobenzenesulfonyl chloride (98-60-2) → 6-bromo-2-[(4-chlorophenylsulfonyl)methyl]-3-nitroimidazo[1,2-a]pyridine (913530-53-7)

Guidance literature:

With sodium hydrogencarbonate; sodium sulfite; In water; at 120 ℃; Microwave irradiation;

DOI:10.1016/j.bmc.2013.09.002

Reference yield:

5-bromo-2-pyridylamine (1072-97-5) → 6-bromo-2-[(4-chlorophenylsulfonyl)methyl]-3-nitroimidazo[1,2-a]pyridine (913530-53-7)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / 78 °C

2: nitric acid; sulfuric acid / 20 °C

3: sodium hydrogencarbonate; sodium sulfite / water / 120 °C / Microwave irradiation

With sulfuric acid; nitric acid; sodium hydrogencarbonate; sodium sulfite; In ethanol; water;

DOI:10.1016/j.bmc.2013.09.002

upstream raw materials:

sodium p-chlorobenzenesulphinate

5-bromo-2-pyridylamine

4-chlorobenzenesulfonyl chloride

6-bromo-2-(chloromethyl)imidazo[1,2-a]pyridine

Downstream raw materials:

2-(4-chlorophenyl)sulfonylmethyl-6-(4-methoxyphenyl)-3-nitroimidazo[1,2-a]pyridine

2-(4-chlorophenyl)sulfonylmethyl-6-(4-fluorophenyl)-3-nitroimidazo[1,2-a]pyridine

2-(4-chlorophenyl)sulfonylmethyl-3-nitro-6-[3-(trifluoromethyl)phenyl]imidazo[1,2-a]pyridine

2-(4-chlorophenyl)sulfonylmethyl-6-(naphthalen-2-yl)-3-nitroimidazo[1,2-a]pyridine