6-Bromo-2-(chloromethyl)imidazo[1,2-a]pyridine

Base Information

• Chemical Name: 6-Bromo-2-(chloromethyl)imidazo[1,2-a]pyridine
• CAS No.: 136117-72-1
• Molecular Formula: C8H6BrClN2
• Molecular Weight: 245.506
• Hs Code.: 2933990090
• European Community (EC) Number: 802-706-1
• ChEMBL ID: CHEMBL2441889
• DSSTox Substance ID: DTXSID20469610
• Nikkaji Number: J2.643.491B
• Wikidata: Q72452978
• Mol file: 136117-72-1.mol

Synonyms:6-Bromo-2-(chloromethyl)imidazo[1,2-a]pyridine;136117-72-1;6-Bromo-2-chloromethylimidazo[1,2-a]pyridine;6-BROMO-2-CHLOROMETHYL-IMIDAZO[1,2-A]PYRIDINE;6-Bromo-2-(chloromethyl)H-imidazo[1,2-a]pyridine;SCHEMBL5760557;CHEMBL2441889;DTXSID20469610;YEXHHHNCGSIJLI-UHFFFAOYSA-N;AKOS000164143;AB28946;AS-31804;CS-0084903;FT-0685150;EN300-58200;6-bromo-2-chloromethylimidazo-[1,2-a]pyridine;A807030;W-205482;6-Bromo-2-chloromethylimidazo[1,2-a]pyridine, AldrichCPR

Chemical Property of 6-Bromo-2-(chloromethyl)imidazo[1,2-a]pyridine

Chemical Property:

• Refractive Index: 1.679
• PSA: 17.30000
• Density: 1.73g/cm³
• LogP: 2.83560
• Storage Temp.: 2-8°C
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 243.94029
• Heavy Atom Count: 12
• Complexity: 167

Purity/Quality:

97% ^*data from raw suppliers

6-Bromo-2-chloromethylimidazo[1,2-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=NC(=CN2C=C1Br)CCl

Technology Process of 6-Bromo-2-(chloromethyl)imidazo[1,2-a]pyridine

There total 5 articles about 6-Bromo-2-(chloromethyl)imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

5-bromo-2-pyridylamine (1072-97-5) + 1,3-Dichloroacetone (534-07-6) → 6-bromo-2-(chloromethyl)imidazo[1,2-a]pyridine (136117-72-1)

Guidance literature:

In ethanol; at 78 ℃;

DOI:10.1016/j.bmc.2013.09.002

Reference yield: 10.0%

5-bromo-2-pyridylamine (1072-97-5) + 1,2-dimethoxyethane (110-71-4) + 1,3-Dichloroacetone (534-07-6) → 6-bromo-2-(chloromethyl)imidazo[1,2-a]pyridine (136117-72-1)

Guidance literature:

In ethanol;

Reference yield:

6-bromo-2-hydroxymethylimidazo<1,2-a>pyridine (136117-71-0) → 6-bromo-2-(chloromethyl)imidazo[1,2-a]pyridine (136117-72-1)

Guidance literature:

With thionyl chloride; In dichloromethane; for 2h; Yield given; Ambient temperature;

DOI:10.1248/cpb.39.1556

upstream raw materials:

6-bromo-2-hydroxymethylimidazo<1,2-a>pyridine

5-bromo-2-pyridylamine

1,3-Dichloroacetone

ethyl 6-bromoimidazo<1,2-a>pyridine-2-carboxylate

Downstream raw materials:

6-bromo-2-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]imidazo[1,2-a]pyridine

6-Bromo-2-[[4-(2,4-dichlorophenyl)-1-piperazinyl]methyl]-imidazo[1,2-a]pyridine

6-phenyl-2-(thien-3-ylmethyl)imidazo[1,2-a]pyridine

2-benzyl-6-(thien-3-yl)imidazo[1,2-a]pyridine