2-(4-Fluoro-benzoyl)-4-methyl-3-(2-oxo-2-phenyl-ethyl)-pentanoic acid ethyl ester

Base Information

Chemical Name:2-(4-Fluoro-benzoyl)-4-methyl-3-(2-oxo-2-phenyl-ethyl)-pentanoic acid ethyl ester
CAS No.:129122-36-7
Molecular Formula:C₂₃H₂₅FO₄
Molecular Weight:384.448
Hs Code.:

Synonyms:2-(4-Fluoro-benzoyl)-4-methyl-3-(2-oxo-2-phenyl-ethyl)-pentanoic acid ethyl ester

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Chemical Property of 2-(4-Fluoro-benzoyl)-4-methyl-3-(2-oxo-2-phenyl-ethyl)-pentanoic acid ethyl ester

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Technology Process of 2-(4-Fluoro-benzoyl)-4-methyl-3-(2-oxo-2-phenyl-ethyl)-pentanoic acid ethyl ester

There total 1 articles about 2-(4-Fluoro-benzoyl)-4-methyl-3-(2-oxo-2-phenyl-ethyl)-pentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-86-2
acetophenone

: 129122-36-7
2-(4-Fluoro-benzoyl)-4-methyl-3-(2-oxo-2-phenyl-ethyl)-pentanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: EtONa / ethanol / 15 h / Ambient temperature

2: EtONa / ethanol / 4.5 h / Ambient temperature

With sodium ethanolate; In ethanol;
DOI:10.1021/jm00113a019

Reference yield:

: 129122-36-7
2-(4-Fluoro-benzoyl)-4-methyl-3-(2-oxo-2-phenyl-ethyl)-pentanoic acid ethyl ester

: (S)-4-({2-[2-(4-Fluoro-phenyl)-4-isopropyl-6-phenyl-pyridin-3-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

2: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

3: Dess-Martin periodinane, tert-butyl alcohol / CH₂Cl₂ / 0.5 h / Ambient temperature

4: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

5: n-BuLi / tetrahydrofuran / 1 h / -78 °C

6: 1.) AIBN, tri-n-butyltin hydride, 2.) I₂ / 1.) 120 deg C - 140 deg C, 3 h, 2.) Et₂O, RT, 45 min

7: 1.) tert-butyllithium / 1.) THF, pentane, -100 deg C, 25 min, 2.) THF, pentane, from -100 deg C to -78 deg C, 30 min

8: tetra-n-butylammonium fluoride, HOAc / tetrahydrofuran / 19 h / Ambient temperature

9: H₂ / 10percent Pd/C / methanol / 72 h / 2585.7 Torr

With lithium aluminium tetrahydride; n-butyllithium; copper diacetate; 2,2'-azobis(isobutyronitrile); ammonium acetate; tetrabutyl ammonium fluoride; hydrogen; iodine; tert.-butyl lithium; tri-n-butyl-tin hydride; Dess-Martin periodane; acetic acid; triphenylphosphine; tert-butyl alcohol; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetic acid;
DOI:10.1021/jm00113a019