Technology Process of (±)-thalictricavine
There total 7 articles about (±)-thalictricavine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate;
In
ethanol;
for 2h;
Heating;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: CH2Cl2 / 24 h / 20 °C
2.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C
3.1: Et3N / CH2Cl2 / 0.33 h / 0 °C
4.1: SnCl4 / CH2Cl2 / 1 h / 0 °C
5.1: LDA / tetrahydrofuran / 1 h / -78 °C
5.2: 80 percent / tetrahydrofuran / 1 h / 20 °C
6.1: 88 percent / Raney Ni / ethanol / 2 h / Heating
7.1: POCl3; K2CO3 / acetonitrile / 2 h / 60 °C
8.1: NaBH4 / methanol / 1 h / 20 °C
9.1: NaBH4 / methanol / 1 h / 20 °C
With
sodium tetrahydroborate; lithium aluminium tetrahydride; tin(IV) chloride; nickel; potassium carbonate; triethylamine; lithium diisopropyl amide; trichlorophosphate;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile;
1.1: Condensation / 2.1: Reduction / 3.1: Acylation / 4.1: Cyclization / 5.1: Metallation / 5.2: Methylation / 6.1: desulfurization; debromination / 7.1: Bischler-Napieralski reaction / 8.1: Reduction / 9.1: Reduction;
DOI:10.1248/cpb.48.399
- Guidance literature:
-
Multi-step reaction with 2 steps
1: NaOAc / acetic acid
2: NaBH4 / methanol
With
sodium tetrahydroborate; sodium acetate;
In
methanol; acetic acid;
1: Methylation / 2: Reduction;
DOI:10.1016/S0040-4020(00)00945-5