bis(2-cyanoethyl) 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate

Base Information

Chemical Name:bis(2-cyanoethyl) 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate
CAS No.:442682-35-1
Molecular Formula:C₂₂H₂₁F₂N₃O₅
Molecular Weight:445.423
Hs Code.:

Synonyms:bis(2-cyanoethyl) 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of bis(2-cyanoethyl) 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate

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Technology Process of bis(2-cyanoethyl) 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate

There total 1 articles about bis(2-cyanoethyl) 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 71653-64-0
o-difluoromethoxybenzaldehyde

: 65193-87-5
2-cyanoethylacetoacetate

: 442682-35-1
bis(2-cyanoethyl) 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate

Guidance literature:: With ammonium hydroxide; In ethanol; for 6h; Heating;
DOI:10.1016/S0957-4166(02)00022-8

Reference yield: 73.0%

: 442682-35-1
bis(2-cyanoethyl) 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate

: 442682-36-2
4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylic acid

Guidance literature:: With potassium hydroxide; In ethanol; at 20 ℃; for 2h;
DOI:10.1016/S0957-4166(02)00022-8

Reference yield:

: 442682-35-1
bis(2-cyanoethyl) 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate

: (-)-3-methyl 5-(2-propoxyethyl) (4R)-4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 73 percent / KOH / ethanol / 2 h / 20 °C

2.1: 1.17 g / dimethylformamide / 18 h

3.1: 55 percent / Candida rugosa lipase / diisopropyl ether; H₂O / 3.5 h / 20 °C

4.1: K₂CO₃ / dimethylformamide / 2 h / 20 °C

4.2: 87 percent / dimethylformamide / 2 h / 20 °C

5.1: KOH / ethanol

6.1: SOCl₂

7.1: dimethylformamide

With potassium hydroxide; thionyl chloride; potassium carbonate; Candida rugosa lipase; In ethanol; di-isopropyl ether; water; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(02)00022-8