4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylic acid

Base Information

Chemical Name:4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylic acid
CAS No.:442682-36-2
Molecular Formula:C₁₆H₁₅F₂NO₅
Molecular Weight:339.296
Hs Code.:

Synonyms:4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylic acid

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Chemical Property of 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylic acid

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Technology Process of 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylic acid

There total 3 articles about 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 442682-35-1
bis(2-cyanoethyl) 4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate

: 442682-36-2
4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylic acid

Guidance literature:: With potassium hydroxide; In ethanol; at 20 ℃; for 2h;
DOI:10.1016/S0957-4166(02)00022-8

Reference yield: 55.0%

: 442682-38-4
bis[(isobutyryloxy)methyl] 4-[2-(difluoromethoxy)phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

: 442682-36-2
4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylic acid

: 442682-40-8
(-)-(4R)-4-[2-(difluoromethoxy)phenyl]-5-{[(isobutyryloxy)methoxy]carbonyl}-2,6-dimethyl-1,4-dihydro-3-pyridinecarboxylic acid

Guidance literature:: With Candida rugosa lipase; In di-isopropyl ether; water; at 20 ℃; for 3.5h;
DOI:10.1016/S0957-4166(02)00022-8

Reference yield:

: 71653-64-0
o-difluoromethoxybenzaldehyde

: 442682-36-2
4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 38 percent / aq. NH₃ / ethanol / 6 h / Heating

2: 73 percent / KOH / ethanol / 2 h / 20 °C

With potassium hydroxide; ammonium hydroxide; In ethanol; 1: Hantzsch cyclization;
DOI:10.1016/S0957-4166(02)00022-8