(-)-(4R)-4-[2-(difluoromethoxy)phenyl]-5-{[(isobutyryloxy)methoxy]carbonyl}-2,6-dimethyl-1,4-dihydro-3-pyridinecarboxylic acid

Base Information

Chemical Name:(-)-(4R)-4-[2-(difluoromethoxy)phenyl]-5-{[(isobutyryloxy)methoxy]carbonyl}-2,6-dimethyl-1,4-dihydro-3-pyridinecarboxylic acid
CAS No.:442682-40-8
Molecular Formula:C₂₁H₂₃F₂NO₇
Molecular Weight:439.413
Hs Code.:

Synonyms:(-)-(4R)-4-[2-(difluoromethoxy)phenyl]-5-{[(isobutyryloxy)methoxy]carbonyl}-2,6-dimethyl-1,4-dihydro-3-pyridinecarboxylic acid

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Chemical Property of (-)-(4R)-4-[2-(difluoromethoxy)phenyl]-5-{[(isobutyryloxy)methoxy]carbonyl}-2,6-dimethyl-1,4-dihydro-3-pyridinecarboxylic acid

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Technology Process of (-)-(4R)-4-[2-(difluoromethoxy)phenyl]-5-{[(isobutyryloxy)methoxy]carbonyl}-2,6-dimethyl-1,4-dihydro-3-pyridinecarboxylic acid

There total 4 articles about (-)-(4R)-4-[2-(difluoromethoxy)phenyl]-5-{[(isobutyryloxy)methoxy]carbonyl}-2,6-dimethyl-1,4-dihydro-3-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 442682-38-4
bis[(isobutyryloxy)methyl] 4-[2-(difluoromethoxy)phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate

: 442682-36-2
4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylic acid

: 442682-40-8
(-)-(4R)-4-[2-(difluoromethoxy)phenyl]-5-{[(isobutyryloxy)methoxy]carbonyl}-2,6-dimethyl-1,4-dihydro-3-pyridinecarboxylic acid

Guidance literature:: With Candida rugosa lipase; In di-isopropyl ether; water; at 20 ℃; for 3.5h;
DOI:10.1016/S0957-4166(02)00022-8

Reference yield:

: 71653-64-0
o-difluoromethoxybenzaldehyde

: 442682-40-8
(-)-(4R)-4-[2-(difluoromethoxy)phenyl]-5-{[(isobutyryloxy)methoxy]carbonyl}-2,6-dimethyl-1,4-dihydro-3-pyridinecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 38 percent / aq. NH₃ / ethanol / 6 h / Heating

2: 73 percent / KOH / ethanol / 2 h / 20 °C

3: 1.17 g / dimethylformamide / 18 h

4: 55 percent / Candida rugosa lipase / diisopropyl ether; H₂O / 3.5 h / 20 °C

With potassium hydroxide; ammonium hydroxide; Candida rugosa lipase; In ethanol; di-isopropyl ether; water; N,N-dimethyl-formamide; 1: Hantzsch cyclization;
DOI:10.1016/S0957-4166(02)00022-8

Reference yield:

: 442682-36-2
4-[2-(difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylic acid

: 442682-40-8
(-)-(4R)-4-[2-(difluoromethoxy)phenyl]-5-{[(isobutyryloxy)methoxy]carbonyl}-2,6-dimethyl-1,4-dihydro-3-pyridinecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.17 g / dimethylformamide / 18 h

2: 55 percent / Candida rugosa lipase / diisopropyl ether; H₂O / 3.5 h / 20 °C

With Candida rugosa lipase; In di-isopropyl ether; water; N,N-dimethyl-formamide;
DOI:10.1016/S0957-4166(02)00022-8