3-Chloro-5-(trifluoromethyl)pyridine-2-thiol

Base Information

Chemical Name:3-Chloro-5-(trifluoromethyl)pyridine-2-thiol
CAS No.:76041-74-2
Molecular Formula:C6H3 Cl F3 N S
Molecular Weight:213.61
Hs Code.:2933399990
European Community (EC) Number:670-842-7
DSSTox Substance ID:DTXSID20353242
Wikidata:Q82130713
Mol file:76041-74-2.mol

Synonyms:3-chloro-5-(trifluoromethyl)pyridine-2-thiol;76041-74-2;3-chloro-5-(trifluoromethyl)-2-pyridinylhydrosulfide;3-chloro-5-(trifluoromethyl)-1H-pyridine-2-thione;3-Chloro-2-mercapto-5-(trifluoromethyl)pyridine;3-Chloro-5-trifluoromethylpyridine-2-thiol;3-chloro-5-(trifluoromethyl)-2-pyridinyl hydrosulfide;Maybridge1_008679;AI-204/31703046;SCHEMBL3464720;HMS566C11;DTXSID20353242;MFCD00153104;AKOS000200406;3-Chloro-2-thio-5-(trifluoromethyl)pyridine;3-Chloro-5-trifluoromethyl-pyridine-2-thiol;CS-0236714;FT-0615432;3-chloro-2-mercapto-5-trifluoromethylpyridine;EN300-17241;12G-041;J-512257;Z203045704;3-chloro-5-(trifluoromethyl)pyridine-2-thiol, AldrichCPR

Suppliers and Price of 3-Chloro-5-(trifluoromethyl)pyridine-2-thiol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
3-Chloro-5-(trifluoromethyl)-2-pyridinylhydrosulfide >95%
1g
$ 228.00

Matrix Scientific
3-Chloro-5-(trifluoromethyl)-2-pyridinylhydrosulfide >95%
500mg
$ 181.00

Matrix Scientific
3-Chloro-5-(trifluoromethyl)-2-pyridinylhydrosulfide >95%
5g
$ 524.00

Crysdot
3-Chloro-5-(trifluoromethyl)pyridine-2-thiol 95+%
5g
$ 414.00

Chemenu
3-Chloro-5-(trifluoromethyl)-2-pyridinylhydrosulfide 95%
5g
$ 391.00

Atlantic Research Chemicals
3-Chloro-5-(trifluoromethyl)pyridine-2-thiol 95%
250mgs:
$ 21.21

Apolloscientific
3-Chloro-2-thio-5-(trifluoromethyl)pyridine tech
1g
$ 35.00

American Custom Chemicals Corporation
3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYLHYDROSULFIDE 95.00%
5G
$ 1168.42

American Custom Chemicals Corporation
3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYLHYDROSULFIDE 95.00%
2.5G
$ 983.88

American Custom Chemicals Corporation
3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYLHYDROSULFIDE 95.00%
1G
$ 721.57

Total 21 raw suppliers

Chemical Property of 3-Chloro-5-(trifluoromethyl)pyridine-2-thiol

Chemical Property:

Vapor Pressure:0.187mmHg at 25°C
Melting Point:145 °C
Boiling Point:218.3ºC at 760 mmHg
PKA:6.66±0.60(Predicted)
Flash Point:85.8ºC
PSA：51.69000
Density:1.56±0.1 g/cm3(Predicted)
LogP:3.04250
Storage Temp.:2-8°C
Sensitive.:Stench
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:212.9626825
Heavy Atom Count:12
Complexity:279

Purity/Quality:

99%, ^*data from raw suppliers

3-Chloro-5-(trifluoromethyl)-2-pyridinylhydrosulfide >95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi,T
Statements: 36/37/38-25
Safety Statements: 26-36-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C(=S)NC=C1C(F)(F)F)Cl

Technology Process of 3-Chloro-5-(trifluoromethyl)pyridine-2-thiol

There total 2 articles about 3-Chloro-5-(trifluoromethyl)pyridine-2-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69045-84-7
2,3-dichloro-5-trifluoromethylpyridine

: 76041-74-2
3-chloro-5-(trifluoromethyl)pyridine-2-thiol

Guidance literature:: With potassium hydroxide; water; thiourea; Yield given. Multistep reaction; 1) ethanol, reflux, 3h, 2) ethanol, reflux, 1h;

Reference yield:

: 69045-83-6
2,3-dichloro-5-(trichloromethyl)pyridine

: 76041-74-2
3-chloro-5-(trifluoromethyl)pyridine-2-thiol

Guidance literature:: Multi-step reaction with 2 steps

1: 80.4 percent / antimony trifluoride / 0.17 h / Heating; Irradiation

2: 1) thiourea, 2) KOH, water / 1) ethanol, reflux, 3h, 2) ethanol, reflux, 1h

With potassium hydroxide; water; antimony(III) fluoride; thiourea;

Reference yield: 86.0%

: 76041-74-2
3-chloro-5-(trifluoromethyl)pyridine-2-thiol

: 292638-37-0
2-chloro-5-nitro-N-(p-tolyl)benzamide

: 1421846-72-1
8-nitro-11-(p-tolyl)-3-(trifluoromethyl)benzo[f]pyrido[3,2-b][1,4]thiazepin-10(11H)one

Guidance literature:: With potassium hydroxide; In dimethyl sulfoxide; at 20 - 150 ℃; for 4.25h; Inert atmosphere; Green chemistry;
DOI:10.1021/co300139s