2-DIMETHYLAMINO-6-HYDROXYPURINE

Base Information

• Chemical Name: 2-DIMETHYLAMINO-6-HYDROXYPURINE
• CAS No.: 1445-15-4
• Molecular Formula: C7H9 N5 O
• Molecular Weight: 179.18
• Hs Code.: 2933990090
• Mol file: 1445-15-4.mol

Synonyms:6H-Purin-6-one,2-(dimethylamino)-1,7-dihydro- (9CI); Guanine, N,N-dimethyl- (6CI,7CI,8CI);N2,N2-Dimethylguanine; NSC 515541

Chemical Property of 2-DIMETHYLAMINO-6-HYDROXYPURINE

Chemical Property:

• Vapor Pressure: 0.00424mmHg at 25°C
• Melting Point: 350-355°C dec.
• Boiling Point: 455.5°Cat760mmHg
• Flash Point: 229.3°C
• PSA: 77.93000
• Density: 1.58g/cm³
• LogP: 0.12450
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly, Heated), Methanol (Slightly, Heated)

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-Dimethylamino-6-hydroxypurine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-DiMethylaMino-6-hydroxypurine is a useful synthetic intermediate A useful synthetic intermediate.

Technology Process of 2-DIMETHYLAMINO-6-HYDROXYPURINE

There total 6 articles about 2-DIMETHYLAMINO-6-HYDROXYPURINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

7-Benzyl-2-dimethylamino-1,7-dihydro-purin-6-one → 2-(dimethylamino)-1,7-dihydro-6H-purin-6-one (1445-15-4)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In water; at 85 - 90 ℃;

DOI:10.1007/bf01169255

Reference yield:

2-methylsulfanyl-1,7(9)-dihydro-purin-6-one (5446-89-9) + dimethyl amine (124-40-3) → 2-(dimethylamino)-1,7-dihydro-6H-purin-6-one (1445-15-4)

Guidance literature:

With methanol; at 140 ℃;

DOI:10.1021/ja01582a060

Reference yield:

7-benzyl-2-chloro-1,7-dihydro-purin-6-one (56025-88-8) → 2-(dimethylamino)-1,7-dihydro-6H-purin-6-one (1445-15-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / H₂O / 5 h / 140 - 150 °C

2: 72 percent / H₂, conc. HCl / Pd/C / H₂O / 85 - 90 °C

With hydrogenchloride; hydrogen; palladium on activated charcoal; In water;

DOI:10.1007/bf01169255

upstream raw materials:

2-methylsulfanyl-1,7⁽⁹⁾-dihydro-purin-6-one

dimethyl amine

7-benzyl-2-chloro-1,7-dihydro-purin-6-one

2-thioxanthine

Downstream raw materials:

N₂,N₂-dimethylguanosine

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