Technology Process of phenyl 2-(benzyloxy)-3-bromo-5-fluoro-4-formyl-6-methylbenzoate
There total 7 articles about phenyl 2-(benzyloxy)-3-bromo-5-fluoro-4-formyl-6-methylbenzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
phenyl 2-(benzyloxy)-3-bromo-5-fluoro-6-methylbenzoate;
With
n-butyllithium; diisopropylamine; lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 ℃;
for 0.166667h;
N,N-dimethyl-formamide;
In
tetrahydrofuran;
at -78 - -20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 25 °C
1.2: 12 h / 25 °C
2.1: boron tribromide / dichloromethane / 1.5 h / -78 - 25 °C
3.1: bromine; acetic acid / 2 h / 20 °C
4.1: potassium carbonate / acetone / 3 h / 0 - 50 °C
5.1: lithium diisopropyl amide; diisopropylamine; n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C
5.2: 1 h / -78 - -20 °C
With
n-butyllithium; oxalyl dichloride; bromine; boron tribromide; potassium carbonate; acetic acid; diisopropylamine; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran / 2 h / -78 °C
1.2: 2 h / -78 - 25 °C
2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 25 °C
2.2: 12 h / 25 °C
3.1: boron tribromide / dichloromethane / 1.5 h / -78 - 25 °C
4.1: bromine; acetic acid / 2 h / 20 °C
5.1: potassium carbonate / acetone / 3 h / 0 - 50 °C
6.1: lithium diisopropyl amide; diisopropylamine; n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C
6.2: 1 h / -78 - -20 °C
With
n-butyllithium; oxalyl dichloride; N,N,N,N,-tetramethylethylenediamine; bromine; sec.-butyllithium; boron tribromide; potassium carbonate; acetic acid; diisopropylamine; lithium diisopropyl amide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;
