diethyl {4-[(benzyloxy)(propan-2-yl)amino]-4-oxo-1-phenylbutyl}phosphonate

Base Information

Chemical Name:diethyl {4-[(benzyloxy)(propan-2-yl)amino]-4-oxo-1-phenylbutyl}phosphonate
CAS No.:1332895-38-1
Molecular Formula:C₂₄H₃₄NO₅P
Molecular Weight:447.511
Hs Code.:

Synonyms:diethyl {4-[(benzyloxy)(propan-2-yl)amino]-4-oxo-1-phenylbutyl}phosphonate

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Chemical Property of diethyl {4-[(benzyloxy)(propan-2-yl)amino]-4-oxo-1-phenylbutyl}phosphonate

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Technology Process of diethyl {4-[(benzyloxy)(propan-2-yl)amino]-4-oxo-1-phenylbutyl}phosphonate

There total 4 articles about diethyl {4-[(benzyloxy)(propan-2-yl)amino]-4-oxo-1-phenylbutyl}phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 96982-61-5
C₁₄H₂₁O₅P

: 136943-84-5
O-benzyl-N-isopropylhydroxylamine

: 1332895-38-1
diethyl {4-[(benzyloxy)(propan-2-yl)amino]-4-oxo-1-phenylbutyl}phosphonate

Guidance literature:: C₁₄H₂₁O₅P; With oxalyl dichloride; In N,N-dimethyl-formamide; toluene; at 0 - 20 ℃; for 2h;

O-benzyl-N-isopropylhydroxylamine; With pyridine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm200694q

Reference yield:

: 1258145-84-4
C₁₆H₂₅O₅P

: 1332895-38-1
diethyl {4-[(benzyloxy)(propan-2-yl)amino]-4-oxo-1-phenylbutyl}phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / water; acetone / 3 h / 50 °C

2.1: selenium(IV) oxide; dihydrogen peroxide / tetrahydrofuran / 4 h / 65 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide; toluene / 2 h / 0 - 20 °C

3.2: 20 °C

With hydrogenchloride; selenium(IV) oxide; oxalyl dichloride; dihydrogen peroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/jm200694q

Reference yield:

: 1155705-57-9
diethyl 4-oxo-1-phenylbutylphosphonate

: 1332895-38-1
diethyl {4-[(benzyloxy)(propan-2-yl)amino]-4-oxo-1-phenylbutyl}phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: selenium(IV) oxide; dihydrogen peroxide / tetrahydrofuran / 4 h / 65 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide; toluene / 2 h / 0 - 20 °C

2.2: 20 °C

With selenium(IV) oxide; oxalyl dichloride; dihydrogen peroxide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm200694q