1-(4-biphenylyl)-1-oxo-5(S)-2,5-di[(tert-butoxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Base Information

Chemical Name:1-(4-biphenylyl)-1-oxo-5(S)-2,5-di[(tert-butoxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
CAS No.:191594-82-8
Molecular Formula:C₃₃H₄₁N₃O₆
Molecular Weight:575.705
Hs Code.:

Synonyms:1-(4-biphenylyl)-1-oxo-5(S)-2,5-di[(tert-butoxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

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Chemical Property of 1-(4-biphenylyl)-1-oxo-5(S)-2,5-di[(tert-butoxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

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Technology Process of 1-(4-biphenylyl)-1-oxo-5(S)-2,5-di[(tert-butoxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

There total 6 articles about 1-(4-biphenylyl)-1-oxo-5(S)-2,5-di[(tert-butoxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 870-46-2
t-butoxycarbonylhydrazine

: 191594-82-8
1-(4-biphenylyl)-1-oxo-5(S)-2,5-di[(tert-butoxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Guidance literature:: Multi-step reaction with 3 steps

1: 52 percent / H₂, AcOH / Raney Ni / methanol / 750.06 Torr / Ambient temperature

2: NaBH₃CN, TsOH / 1,2-dimethoxy-ethane / Ambient temperature

3: 1.) aq. borax; 2.) MTBD

With borax; hydrogen; sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; 1-methyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine; nickel; In methanol; 1,2-dimethoxyethane;
DOI:10.1016/S0040-4039(98)00897-1

Reference yield:

: 72155-45-4
Boc-L-phenylalaninal

: 191594-82-8
1-(4-biphenylyl)-1-oxo-5(S)-2,5-di[(tert-butoxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / N-benzyl cinchoninium chloride / H₂O; CH₂Cl₂ / 0 °C

2: 52 percent / H₂, AcOH / Raney Ni / methanol / 750.06 Torr / Ambient temperature

3: NaBH₃CN, TsOH / 1,2-dimethoxy-ethane / Ambient temperature

4: 1.) aq. borax; 2.) MTBD

With borax; N-benzylcinchoninium chloride; hydrogen; sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; 1-methyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine; nickel; In methanol; 1,2-dimethoxyethane; dichloromethane; water;
DOI:10.1016/S0040-4039(98)00897-1

Reference yield:

: 211676-31-2
1-(R)-Cyano-2(S)-(N-tert-butoxycarbonylamino)-3-phenylpropyl 4-[phenyl]-benzoate

: 191594-82-8
1-(4-biphenylyl)-1-oxo-5(S)-2,5-di[(tert-butoxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Guidance literature:: Multi-step reaction with 3 steps

1: 52 percent / H₂, AcOH / Raney Ni / methanol / 750.06 Torr / Ambient temperature

2: NaBH₃CN, TsOH / 1,2-dimethoxy-ethane / Ambient temperature

3: 1.) aq. borax; 2.) MTBD

With borax; hydrogen; sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; 1-methyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine; nickel; In methanol; 1,2-dimethoxyethane;
DOI:10.1016/S0040-4039(98)00897-1