Biphenyl-4-carboxylic acid (1R,2S)-2-tert-butoxycarbonylamino-1-(tert-butoxycarbonyl-hydrazonomethyl)-3-phenyl-propyl ester

Base Information

Chemical Name:Biphenyl-4-carboxylic acid (1R,2S)-2-tert-butoxycarbonylamino-1-(tert-butoxycarbonyl-hydrazonomethyl)-3-phenyl-propyl ester
CAS No.:191594-81-7
Molecular Formula:C₃₃H₃₉N₃O₆
Molecular Weight:573.689
Hs Code.:

Synonyms:Biphenyl-4-carboxylic acid (1R,2S)-2-tert-butoxycarbonylamino-1-(tert-butoxycarbonyl-hydrazonomethyl)-3-phenyl-propyl ester

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Chemical Property of Biphenyl-4-carboxylic acid (1R,2S)-2-tert-butoxycarbonylamino-1-(tert-butoxycarbonyl-hydrazonomethyl)-3-phenyl-propyl ester

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Technology Process of Biphenyl-4-carboxylic acid (1R,2S)-2-tert-butoxycarbonylamino-1-(tert-butoxycarbonyl-hydrazonomethyl)-3-phenyl-propyl ester

There total 2 articles about Biphenyl-4-carboxylic acid (1R,2S)-2-tert-butoxycarbonylamino-1-(tert-butoxycarbonyl-hydrazonomethyl)-3-phenyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 870-46-2
t-butoxycarbonylhydrazine

: 211676-31-2
1-(R)-Cyano-2(S)-(N-tert-butoxycarbonylamino)-3-phenylpropyl 4-[phenyl]-benzoate

: 191594-81-7
Biphenyl-4-carboxylic acid (1R,2S)-2-tert-butoxycarbonylamino-1-(tert-butoxycarbonyl-hydrazonomethyl)-3-phenyl-propyl ester

: Biphenyl-4-carboxylic acid (1S,2S)-2-tert-butoxycarbonylamino-1-(tert-butoxycarbonyl-hydrazonomethyl)-3-phenyl-propyl ester

Guidance literature:: With hydrogen; acetic acid; nickel; In methanol; under 750.06 Torr; Ambient temperature;
DOI:10.1016/S0040-4039(98)00897-1

Reference yield:

: 72155-45-4
Boc-L-phenylalaninal

: 191594-81-7
Biphenyl-4-carboxylic acid (1R,2S)-2-tert-butoxycarbonylamino-1-(tert-butoxycarbonyl-hydrazonomethyl)-3-phenyl-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / N-benzyl cinchoninium chloride / H₂O; CH₂Cl₂ / 0 °C

2: 52 percent / H₂, AcOH / Raney Ni / methanol / 750.06 Torr / Ambient temperature

With N-benzylcinchoninium chloride; hydrogen; acetic acid; nickel; In methanol; dichloromethane; water;
DOI:10.1016/S0040-4039(98)00897-1

Reference yield:

: 191594-81-7
Biphenyl-4-carboxylic acid (1R,2S)-2-tert-butoxycarbonylamino-1-(tert-butoxycarbonyl-hydrazonomethyl)-3-phenyl-propyl ester

: Biphenyl-4-carboxylic acid (1S,2S)-2-tert-butoxycarbonylamino-1-(N'-tert-butoxycarbonyl-hydrazinomethyl)-3-phenyl-propyl ester

Guidance literature:: With sodium cyanoborohydride; toluene-4-sulfonic acid; In 1,2-dimethoxyethane; Ambient temperature;
DOI:10.1016/S0040-4039(98)00897-1