1-(R)-Cyano-2(S)-(N-tert-butoxycarbonylamino)-3-phenylpropyl 4-[phenyl]-benzoate

Base Information

Chemical Name:1-(R)-Cyano-2(S)-(N-tert-butoxycarbonylamino)-3-phenylpropyl 4-[phenyl]-benzoate
CAS No.:211676-31-2
Molecular Formula:C₂₈H₂₈N₂O₄
Molecular Weight:456.541
Hs Code.:

Synonyms:1-(R)-Cyano-2(S)-(N-tert-butoxycarbonylamino)-3-phenylpropyl 4-[phenyl]-benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(R)-Cyano-2(S)-(N-tert-butoxycarbonylamino)-3-phenylpropyl 4-[phenyl]-benzoate

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Technology Process of 1-(R)-Cyano-2(S)-(N-tert-butoxycarbonylamino)-3-phenylpropyl 4-[phenyl]-benzoate

There total 2 articles about 1-(R)-Cyano-2(S)-(N-tert-butoxycarbonylamino)-3-phenylpropyl 4-[phenyl]-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 72155-45-4
Boc-L-phenylalaninal

: 151-50-8
potassium cyanide

: 211676-31-2
1-(R)-Cyano-2(S)-(N-tert-butoxycarbonylamino)-3-phenylpropyl 4-[phenyl]-benzoate

Guidance literature:: With N-benzylcinchoninium chloride; In dichloromethane; water; at 0 ℃;
DOI:10.1016/S0040-4039(98)00897-1

Reference yield:

: N-benzylcinchoninium chloride

: 72155-45-4
Boc-L-phenylalaninal

: 14002-51-8
4-biphenyl-carboxylic acid chloride

: 211676-31-2
1-(R)-Cyano-2(S)-(N-tert-butoxycarbonylamino)-3-phenylpropyl 4-[phenyl]-benzoate

Guidance literature:: In tetrahydrofuran;

Reference yield: 52.0%

: 870-46-2
t-butoxycarbonylhydrazine

: 211676-31-2
1-(R)-Cyano-2(S)-(N-tert-butoxycarbonylamino)-3-phenylpropyl 4-[phenyl]-benzoate

: 191594-81-7
Biphenyl-4-carboxylic acid (1R,2S)-2-tert-butoxycarbonylamino-1-(tert-butoxycarbonyl-hydrazonomethyl)-3-phenyl-propyl ester

: Biphenyl-4-carboxylic acid (1S,2S)-2-tert-butoxycarbonylamino-1-(tert-butoxycarbonyl-hydrazonomethyl)-3-phenyl-propyl ester

Guidance literature:: With hydrogen; acetic acid; nickel; In methanol; under 750.06 Torr; Ambient temperature;
DOI:10.1016/S0040-4039(98)00897-1