3-[3-(5-amino-3-t-butyl-pyrazol-1-yl)-phenyl]-propionic acid ethyl ester

Base Information

• Chemical Name: 3-[3-(5-amino-3-t-butyl-pyrazol-1-yl)-phenyl]-propionic acid ethyl ester
• CAS No.: 872171-14-7
• Molecular Formula: C₁₈H₂₅N₃O₂
• Molecular Weight: 315.415

Synonyms:3-[3-(5-amino-3-t-butyl-pyrazol-1-yl)-phenyl]-propionic acid ethyl ester

Chemical Property of 3-[3-(5-amino-3-t-butyl-pyrazol-1-yl)-phenyl]-propionic acid ethyl ester

Chemical Property:

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Technology Process of 3-[3-(5-amino-3-t-butyl-pyrazol-1-yl)-phenyl]-propionic acid ethyl ester

There total 2 articles about 3-[3-(5-amino-3-t-butyl-pyrazol-1-yl)-phenyl]-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-(3-hydrazino-phenyl)-propionic acid ethyl ester (897373-51-2) + trimethylacetylacetonitrile (59997-51-2) → 3-[3-(5-amino-3-t-butyl-pyrazol-1-yl)-phenyl]-propionic acid ethyl ester (872171-14-7)

Guidance literature:

In ethanol; Heating / reflux;

Reference yield:

trimethylacetylacetonitrile (59997-51-2) + (E)-ethyl 3-(3-nitrophenyl)acrylate (621-19-2) → 3-[3-(5-amino-3-t-butyl-pyrazol-1-yl)-phenyl]-propionic acid ethyl ester (872171-14-7)

Guidance literature:

In ethanol;

Reference yield: 70.0%

2-Picolinic acid (98-98-6) + 3-[3-(5-amino-3-t-butyl-pyrazol-1-yl)-phenyl]-propionic acid ethyl ester (872171-14-7) → 3-(3-{3-t-butyl-5-[(pyridine-2-carbonyl)-amino]-pyrazol-1-yl}-phenyl)-propionic acid ethyl ester (872171-20-5)

Guidance literature:

With NMM; benzotriazol-1-ol; In N,N-dimethyl-formamide;

upstream raw materials:

trimethylacetylacetonitrile

(E)-ethyl 3-(3-nitrophenyl)acrylate

3-(3-hydrazino-phenyl)-propionic acid ethyl ester

Downstream raw materials:

3-(3-{3-t-butyl-5-[3-(4-fluoro-phenyl)-ureido]-pyrazol-1-yl}-phenyl)-propionic acid ethyl ester

3-(3-{3-t-butyl-5-[3-(4-methoxy-phenyl)-ureido]-pyrazol-1-yl}-phenyl)-propionic acid ethyl ester

3-(3-{3-t-butyl-5-[(isoquinoline-1-carbonyl)-amino]-pyrazol-1-yl}-phenyl)-propionic acid ethyl ester

3-(3-{3-t-butyl-5-[(pyridine-2-carbonyl)-amino]-pyrazol-1-yl}-phenyl)-propionic acid ethyl ester

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