2,6-di-t-butyl-4-methylphenyl trans-(1R,2R)-2-phenylcyclopropane-1-carboxylate

Base Information

Chemical Name:2,6-di-t-butyl-4-methylphenyl trans-(1R,2R)-2-phenylcyclopropane-1-carboxylate
CAS No.:131899-82-6
Molecular Formula:C₂₅H₃₂O₂
Molecular Weight:364.528
Hs Code.:

Synonyms:2,6-di-t-butyl-4-methylphenyl trans-(1R,2R)-2-phenylcyclopropane-1-carboxylate

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Chemical Property of 2,6-di-t-butyl-4-methylphenyl trans-(1R,2R)-2-phenylcyclopropane-1-carboxylate

Chemical Property:

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Technology Process of 2,6-di-t-butyl-4-methylphenyl trans-(1R,2R)-2-phenylcyclopropane-1-carboxylate

There total 6 articles about 2,6-di-t-butyl-4-methylphenyl trans-(1R,2R)-2-phenylcyclopropane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6
styrene

: 125640-92-8
2,6-di-tert-butyl-4-methylphenyl diazoacetate

: 108546-83-4,125641-27-2,125641-28-3,131899-82-6,131899-85-9
2,6-di-tert-butyl-4-methylphenyl trans-2-phenylcyclopropanecarboxylate

Guidance literature:: Rh₂(acam)4; In dichloromethane; for 2h; Heating;

Reference yield:

: 100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6
styrene

: 125640-92-8
2,6-di-tert-butyl-4-methylphenyl diazoacetate

: 131899-82-6
2,6-di-t-butyl-4-methylphenyl trans-(1R,2R)-2-phenylcyclopropane-1-carboxylate

: 2,6-di-t-butyl-4-methylphenyl trans-(1S,2S)-2-phenylcyclopropane-1-carboxylate

Guidance literature:: With (+)-(R,R)-C₂-symmetric bisazaferrocene; copper(I) triflate; In dichloromethane; for 36h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;
DOI:10.1021/ja982488y

Reference yield:

: 128-37-0
2,6-di-tert-butyl-4-methyl-phenol

: 108546-83-4,125641-27-2,125641-28-3,131899-82-6,131899-85-9
2,6-di-tert-butyl-4-methylphenyl trans-2-phenylcyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / triethylamine, methanesulfonyl azide / acetonitrile / 1.) reflux, 2.) RT, 7 h

2: 5percent aq. KOH / acetonitrile / 24 h / Ambient temperature

3: 86 percent / Rh₂(acam)4 / CH₂Cl₂ / 2 h / Heating

With potassium hydroxide; triethylamine; Methanesulfonyl azide; Rh₂(acam)4; In dichloromethane; acetonitrile;