ethyl 4-(4-(2-(N-methylmethylsulfonamido)benzylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)benzoate

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Chemical Name:ethyl 4-(4-(2-(N-methylmethylsulfonamido)benzylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)benzoate
CAS No.:1372262-47-9
Molecular Formula:C₃₀H₄₀N₆O₅SSi
Molecular Weight:624.836
Hs Code.:

Synonyms:ethyl 4-(4-(2-(N-methylmethylsulfonamido)benzylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)benzoate

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Chemical Property of ethyl 4-(4-(2-(N-methylmethylsulfonamido)benzylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)benzoate

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Technology Process of ethyl 4-(4-(2-(N-methylmethylsulfonamido)benzylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)benzoate

There total 8 articles about ethyl 4-(4-(2-(N-methylmethylsulfonamido)benzylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372262-46-8
N-(2-((2-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)methyl)phenyl)-N-methylmethanesulfonamide

: 94-09-7
p-aminoethylbenzoate

: 1372262-47-9
ethyl 4-(4-(2-(N-methylmethylsulfonamido)benzylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)benzoate

Guidance literature:: With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 110 ℃; for 16.083h; Inert atmosphere;

Reference yield:

: 84955-31-7
4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine

: 1372262-47-9
ethyl 4-(4-(2-(N-methylmethylsulfonamido)benzylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 °C

1.2: 2 h / 0 - 80 °C

1.3: pH 8

2.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane / 16 h / Reflux

4.1: sodium t-butanolate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 16.08 h / 110 °C / Inert atmosphere

With hydrogenchloride; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; toluene; 4.1: Buchwald-Hartwig coupling;

Reference yield:

: 90213-66-4
2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine

: 1372262-47-9
ethyl 4-(4-(2-(N-methylmethylsulfonamido)benzylamino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / 1,2-dimethoxyethane / 16 h / Reflux

3: sodium t-butanolate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 16.08 h / 110 °C / Inert atmosphere

With sodium hydride; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; toluene; 3: Buchwald-Hartwig coupling;