2-methoxybenzaldehyde O-methyloxime

Base Information

• Chemical Name: 2-methoxybenzaldehyde O-methyloxime
• CAS No.: 107369-63-1
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.192
• Mol file: 107369-63-1.mol

Synonyms:2-methoxybenzaldehyde O-methyloxime

Chemical Property of 2-methoxybenzaldehyde O-methyloxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methoxybenzaldehyde O-methyloxime

There total 2 articles about 2-methoxybenzaldehyde O-methyloxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

N-methoxylamine hydrochloride (593-56-6) + ortho-anisaldehyde (135-02-4) → 2-methoxybenzaldehyde O-methyloxime (107369-63-1)

Guidance literature:

With pyridine; In ethanol; for 1h; Heating;

DOI:10.1039/b103181n

Reference yield:

(E)-2-hydroxylbenzaldehyde oxime (21013-96-7) + methyl iodide (74-88-4) → 2-methoxybenzaldehyde O-methyloxime (107369-63-1)

Guidance literature:

With silver(l) oxide;

Reference yield: 95.0%

2-methoxybenzaldehyde O-methyloxime (107369-63-1) + (R)-2-(prop-1-en-2-yl)-1-tosylaziridine → (2R,4S)-3-methoxy-2-(2-methoxyphenyl)-4-(prop-1-en-2-yl)-1-tosylimidazolidine

Guidance literature:

With silver hexafluoroantimonate; di-μ-chlorobis(norbornadiene)dirhodium(I); In 1,2-dichloro-ethane; at -5 ℃; for 12h; stereoselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.8b01378

upstream raw materials:

(E)-2-hydroxylbenzaldehyde oxime

methyl iodide

N-methoxylamine hydrochloride

ortho-anisaldehyde

Downstream raw materials:

ortho-anisaldehyde

1-(2-methoxyphenyl)pentan-1-one

salicylonitrile

2-methoxy-benzonitrile

Refernces

• 1、 Sharma, Satyasheel,Kim, Minyoung,Park, Jihye,Kim, Mirim,Kwak, Jong Hwan,Jung, Young Hoon,Oh, Joa Sub,Lee, Youngil,Kim, In Su. "Palladium-catalyzed direct acylation of ketoximes and aldoximes from the alcohol oxidation level through C-H bond activation". . p. 6656 - 6665. Retrieved 2013/11/06.