4-Oxo-pentanoic acid 2-(2-{(2R,3R,4R,5R)-5-[6-(trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethoxy)-ethyl ester

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Chemical Name:4-Oxo-pentanoic acid 2-(2-{(2R,3R,4R,5R)-5-[6-(trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethoxy)-ethyl ester
CAS No.:191853-46-0
Molecular Formula:C₇₆H₆₉N₅O₈
Molecular Weight:1180.41
Hs Code.:

Synonyms:4-Oxo-pentanoic acid 2-(2-{(2R,3R,4R,5R)-5-[6-(trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethoxy)-ethyl ester

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Chemical Property of 4-Oxo-pentanoic acid 2-(2-{(2R,3R,4R,5R)-5-[6-(trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethoxy)-ethyl ester

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Technology Process of 4-Oxo-pentanoic acid 2-(2-{(2R,3R,4R,5R)-5-[6-(trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethoxy)-ethyl ester

There total 2 articles about 4-Oxo-pentanoic acid 2-(2-{(2R,3R,4R,5R)-5-[6-(trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethoxy)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 123-76-2
levulinic acid

: 191853-41-5
2-(2-{(2R,3R,4R,5R)-5-[6-(Trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethoxy)-ethanol

: 191853-46-0
4-Oxo-pentanoic acid 2-(2-{(2R,3R,4R,5R)-5-[6-(trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethoxy)-ethyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1002/hlca.19970800313

Reference yield:

: 191853-38-0
{9-[(2R,3R,4R,5R)-4-(2-{2-[Dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-ethoxy}-ethoxy)-3-trityloxy-5-trityloxymethyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-trityl-amine

: 191853-46-0
4-Oxo-pentanoic acid 2-(2-{(2R,3R,4R,5R)-5-[6-(trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethoxy)-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / Bu₄NF*3H₂O / tetrahydrofuran / Ambient temperature

2: 92 percent / EDC*HCl, DMAP / CH₂Cl₂ / 3 h / Ambient temperature

With dmap; tetrabutyl ammonium fluoride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1002/hlca.19970800313

Reference yield:

: 191853-46-0
4-Oxo-pentanoic acid 2-(2-{(2R,3R,4R,5R)-5-[6-(trityl-amino)-purin-9-yl]-4-trityloxy-2-trityloxymethyl-tetrahydro-furan-3-yloxy}-ethoxy)-ethyl ester

: 191853-67-5
4-Oxo-pentanoic acid 2-(2-{(2R,3R,4R,5R)-2-hydroxymethyl-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-4-[2-(4-nitro-phenyl)-ethoxycarbonyloxy]-tetrahydro-furan-3-yloxy}-ethoxy)-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / 80percent AcOH / H₂O / 0.5 h / 100 °C

2: (NH₂₄)SO₄ / dioxane / 3 h / Heating

3: CH₂Cl₂

4: 80percent AcOH / H₂O / 1 h

5: 73 percent / pyridine / 24 h / Ambient temperature

6: 91 percent / DMAP / CH₂Cl₂ / Ambient temperature

7: 83 percent / 2percent TsOH / methanol; CHCl₃ / 0.25 h / Ambient temperature

With pyridine; dmap; (NH₂₄)SO₄; toluene-4-sulfonic acid; acetic acid; In 1,4-dioxane; methanol; dichloromethane; chloroform; water;
DOI:10.1002/hlca.19970800313