Benzyl-((R)-1-ethyl-4-hydroxy-butyl)-carbamic acid benzyl ester

Base Information

• Chemical Name: Benzyl-((R)-1-ethyl-4-hydroxy-butyl)-carbamic acid benzyl ester
• CAS No.: 124938-16-5
• Molecular Formula: C₂₁H₂₇NO₃
• Molecular Weight: 341.45
• Mol file: 124938-16-5.mol

Synonyms:Benzyl-((R)-1-ethyl-4-hydroxy-butyl)-carbamic acid benzyl ester

Chemical Property of Benzyl-((R)-1-ethyl-4-hydroxy-butyl)-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzyl-((R)-1-ethyl-4-hydroxy-butyl)-carbamic acid benzyl ester

There total 6 articles about Benzyl-((R)-1-ethyl-4-hydroxy-butyl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(E)-(R)-4-(Benzyl-benzyloxycarbonyl-amino)-hex-2-enoic acid methyl ester (124938-15-4) → Benzyl-((R)-1-ethyl-4-hydroxy-butyl)-carbamic acid benzyl ester (124938-16-5)

Guidance literature:

With sodium tetrahydroborate; lithium chloride; In tetrahydrofuran; ethanol; Ambient temperature;

DOI:10.1016/S0040-4039(00)99129-9

Reference yield:

Benzyl-((R)-1-hydroxymethyl-propyl)-carbamic acid benzyl ester (124938-13-2) → Benzyl-((R)-1-ethyl-4-hydroxy-butyl)-carbamic acid benzyl ester (124938-16-5)

Guidance literature:

Multi-step reaction with 3 steps

1: Me₂SO, (COCl)2, Et₃N / CH₂Cl₂ / -78 °C

2: tetrahydrofuran / Ambient temperature

3: 85 percent / NaBH₄, LiCl / ethanol; tetrahydrofuran / Ambient temperature

With sodium tetrahydroborate; oxalyl dichloride; dimethyl sulfoxide; triethylamine; lithium chloride; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1016/S0040-4039(00)99129-9

Reference yield:

benzaldehyde (100-52-7) → Benzyl-((R)-1-ethyl-4-hydroxy-butyl)-carbamic acid benzyl ester (124938-16-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) MgSO₄, molecular sieves 4 Angstroem; 2.) NaBH₄ / 1.) CH₂Cl₂, 25 deg C; 2.) MeOH, rt, 2 h

2: NaOH / H₂O; dioxane / 5 °C

3: Me₂SO, (COCl)2, Et₃N / CH₂Cl₂ / -78 °C

4: tetrahydrofuran / Ambient temperature

5: 85 percent / NaBH₄, LiCl / ethanol; tetrahydrofuran / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; oxalyl dichloride; 4 A molecular sieve; magnesium sulfate; dimethyl sulfoxide; triethylamine; lithium chloride; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;

DOI:10.1016/S0040-4039(00)99129-9

upstream raw materials:

(E)-(R)-4-(Benzyl-benzyloxycarbonyl-amino)-hex-2-enoic acid methyl ester

(2R)-2-(benzylamino)butan-1-ol

Benzyl-((R)-1-formyl-propyl)-carbamic acid benzyl ester

Benzyl-((R)-1-hydroxymethyl-propyl)-carbamic acid benzyl ester

Downstream raw materials:

Benzyl-((R)-1-ethyl-4-oxo-butyl)-carbamic acid benzyl ester

Benzyl-((R)-3-[1,3]dioxolan-2-yl-1-ethyl-propyl)-carbamic acid benzyl ester

Benzyl-((R)-1-ethyl-4-oxo-undecyl)-carbamic acid benzyl ester

Benzyl-((R)-1-ethyl-4-hydroxy-undecyl)-carbamic acid benzyl ester