(E)-(R)-4-(Benzyl-benzyloxycarbonyl-amino)-hex-2-enoic acid methyl ester

Base Information

Chemical Name:(E)-(R)-4-(Benzyl-benzyloxycarbonyl-amino)-hex-2-enoic acid methyl ester
CAS No.:124938-15-4
Molecular Formula:C₂₂H₂₅NO₄
Molecular Weight:367.445
Hs Code.:

Synonyms:(E)-(R)-4-(Benzyl-benzyloxycarbonyl-amino)-hex-2-enoic acid methyl ester

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Chemical Property of (E)-(R)-4-(Benzyl-benzyloxycarbonyl-amino)-hex-2-enoic acid methyl ester

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Technology Process of (E)-(R)-4-(Benzyl-benzyloxycarbonyl-amino)-hex-2-enoic acid methyl ester

There total 6 articles about (E)-(R)-4-(Benzyl-benzyloxycarbonyl-amino)-hex-2-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-52-7
benzaldehyde

: 124938-15-4
(E)-(R)-4-(Benzyl-benzyloxycarbonyl-amino)-hex-2-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) MgSO₄, molecular sieves 4 Angstroem; 2.) NaBH₄ / 1.) CH₂Cl₂, 25 deg C; 2.) MeOH, rt, 2 h

2: NaOH / H₂O; dioxane / 5 °C

3: Me₂SO, (COCl)2, Et₃N / CH₂Cl₂ / -78 °C

4: tetrahydrofuran / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; oxalyl dichloride; 4 A molecular sieve; magnesium sulfate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1016/S0040-4039(00)99129-9

Reference yield:

: 6257-49-4,51977-20-9
(2R)-2-(benzylamino)butan-1-ol

: 124938-15-4
(E)-(R)-4-(Benzyl-benzyloxycarbonyl-amino)-hex-2-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaOH / H₂O; dioxane / 5 °C

2: Me₂SO, (COCl)2, Et₃N / CH₂Cl₂ / -78 °C

3: tetrahydrofuran / Ambient temperature

With sodium hydroxide; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1016/S0040-4039(00)99129-9

Reference yield:

: 124938-13-2
Benzyl-((R)-1-hydroxymethyl-propyl)-carbamic acid benzyl ester

: 124938-15-4
(E)-(R)-4-(Benzyl-benzyloxycarbonyl-amino)-hex-2-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Me₂SO, (COCl)2, Et₃N / CH₂Cl₂ / -78 °C

2: tetrahydrofuran / Ambient temperature

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(00)99129-9