(2,5-dimethyl-1-phenyl-pyrrol-3-yl)-(4-methoxy-phenyl)-ketone

Base Information

• Chemical Name: (2,5-dimethyl-1-phenyl-pyrrol-3-yl)-(4-methoxy-phenyl)-ketone
• CAS No.: 102237-68-3
• Molecular Formula: C₂₀H₁₉NO₂
• Molecular Weight: 305.376
• Mol file: 102237-68-3.mol

Synonyms:(2,5-dimethyl-1-phenyl-pyrrol-3-yl)-(4-methoxy-phenyl)-ketone

Chemical Property of (2,5-dimethyl-1-phenyl-pyrrol-3-yl)-(4-methoxy-phenyl)-ketone

Chemical Property:

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Technology Process of (2,5-dimethyl-1-phenyl-pyrrol-3-yl)-(4-methoxy-phenyl)-ketone

There total 2 articles about (2,5-dimethyl-1-phenyl-pyrrol-3-yl)-(4-methoxy-phenyl)-ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2,5-dimethyl-1-phenyl-1H-pyrrole (83-24-9) + carbon monoxide (201230-82-2) + 4-methoxyphenyl triflate (66107-29-7) → (2,5-dimethyl-1-phenyl-pyrrol-3-yl)-(4-methoxy-phenyl)-ketone (102237-68-3)

Guidance literature:

With 4-methoxypyridine; bis(trimethylsilylmethyl)(cycloocta-1,5-diene)palladium(II); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In acetonitrile; at 130 ℃; for 48h; under 3040.2 Torr;

DOI:10.1039/d0sc03129a

Reference yield:

2,5-dimethyl-1-phenyl-1H-pyrrole (83-24-9) + 4-methoxy-benzoyl chloride (100-07-2) → (2,5-dimethyl-1-phenyl-pyrrol-3-yl)-(4-methoxy-phenyl)-ketone (102237-68-3) + 3,4-bis-(4-methoxy-benzoyl)-2,5-dimethyl-1-phenyl-pyrrole (103098-10-8)

Guidance literature:

With carbon disulfide; tin(IV) chloride;

DOI:10.1021/jo01086a027

upstream raw materials:

2,5-dimethyl-1-phenyl-1H-pyrrole

4-methoxy-benzoyl chloride

carbon monoxide

4-methoxyphenyl triflate