4-hydroxy-5-phenyl-1⁽²⁾H-pyrazole-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 4-hydroxy-5-phenyl-1⁽²⁾H-pyrazole-3-carboxylic acid ethyl ester
• CAS No.: 34035-06-8
• Molecular Formula: C₁₂H₁₂N₂O₃
• Molecular Weight: 232.239
• Mol file: 34035-06-8.mol

Synonyms:4-hydroxy-5-phenyl-1⁽²⁾H-pyrazole-3-carboxylic acid ethyl ester

Chemical Property of 4-hydroxy-5-phenyl-1⁽²⁾H-pyrazole-3-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-hydroxy-5-phenyl-1⁽²⁾H-pyrazole-3-carboxylic acid ethyl ester

There total 7 articles about 4-hydroxy-5-phenyl-1⁽²⁾H-pyrazole-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-diazo-3-carbonyl-4-phenylbutyrate (188475-11-8) → 4-hydroxy-5-phenyl-1(2)H-pyrazole-3-carboxylic acid ethyl ester (34035-06-8)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 24h;

DOI:10.1016/j.bmcl.2006.01.123

Reference yield:

ethyl 3-oxo-4-phenylbutyrate (718-08-1) → 4-hydroxy-5-phenyl-1(2)H-pyrazole-3-carboxylic acid ethyl ester (34035-06-8)

Guidance literature:

Multi-step reaction with 2 steps

1: p-TsN₃; NEt₃ / acetonitrile / 1 h / 15 °C

2: NaH / tetrahydrofuran / 24 h / 0 - 20 °C

With 4-toluenesulfonyl azide; sodium hydride; triethylamine; In tetrahydrofuran; acetonitrile;

DOI:10.1016/j.bmcl.2006.01.123

Reference yield:

phenylacetyl chloride (103-80-0) → 4-hydroxy-5-phenyl-1(2)H-pyrazole-3-carboxylic acid ethyl ester (34035-06-8)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / CH₂Cl₂ / 0 - 20 °C

2: p-TsN₃; NEt₃ / acetonitrile / 1 h / 15 °C

3: NaH / tetrahydrofuran / 24 h / 0 - 20 °C

With pyridine; 4-toluenesulfonyl azide; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1016/j.bmcl.2006.01.123

upstream raw materials:

diazoacetic acid ethyl ester

diethyl 2-phenylmalonate

ethyl 2-diazo-3-carbonyl-4-phenylbutyrate

ethyl 3-oxo-4-phenylbutyrate

Downstream raw materials:

C₂₄H₂₀N₂O₃

C₂₄H₁₇N₅O

C₂₆H₂₄N₂O₅

C₂₄H₁₉N₅O₂