3-(4-fluorophenyl)-3-oxopropanal

Base Information

• Chemical Name: 3-(4-fluorophenyl)-3-oxopropanal
• CAS No.: 115168-89-3
• Molecular Formula: C₉H₇FO₂
• Molecular Weight: 166.152
• Mol file: 115168-89-3.mol

Synonyms:3-(4-fluorophenyl)-3-oxopropanal

Chemical Property of 3-(4-fluorophenyl)-3-oxopropanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-fluorophenyl)-3-oxopropanal

There total 2 articles about 3-(4-fluorophenyl)-3-oxopropanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-(4-fluorophenyl)ethanone (403-42-9) + formic acid ethyl ester (109-94-4) → 3-(4-fluorophenyl)-3-oxopropanal (115168-89-3)

Guidance literature:

1-(4-fluorophenyl)ethanone; With sodium; In toluene; for 0.5h; Cooling with ice;

formic acid ethyl ester; In toluene; at 5 - 20 ℃;

Acidic conditions;

DOI:10.1248/cpb.58.1127

Reference yield:

3-(dimethylamino)-1-(4-fluorophenyl)prop-2-en-1-one (75175-77-8) → 3-(4-fluorophenyl)-3-oxopropanal (115168-89-3)

Guidance literature:

With methanol; In water;

DOI:10.1016/j.ica.2020.120117

Reference yield: 90.0%

N-benzyloxyamine (622-33-3) + 3-(4-fluorophenyl)-3-oxopropanal (115168-89-3) → 3-(4-Fluoro-phenyl)-3-oxo-propionaldehyde O-benzyl-oxime (143620-76-2)

Guidance literature:

In methanol; at 25 - 40 ℃;

DOI:10.1021/jm00100a011

upstream raw materials:

1-(4-fluorophenyl)ethanone

formic acid ethyl ester

3-(dimethylamino)-1-(4-fluorophenyl)prop-2-en-1-one

Downstream raw materials:

1-(4-fluorophenyl)-1,3-propanediol

3-(4-Fluoro-phenyl)-3-oxo-propionaldehyde O-benzyl-oxime

(Z)-3-(Benzyl-methoxy-amino)-1-(4-fluoro-phenyl)-propenone

(Z)-1-(4-Fluoro-phenyl)-3-(hydroxy-phenethyl-amino)-propenone

Refernces

• 1、 Liu, Jinbing,Yi, Wei,Hu, Jianming,Wu, Fengyan,Zhao, Liangzhong,Song, Huacan,Wang, Zhihou. "Design, synthesis and biological evaluation of 3-(4-halophenyl)-3- oxopropanal and their derivatives as novel antibacterial agents". experimental part. p. 1127 - 1131. Retrieved 2010/11/05.
• 2、 Wright, Stephen W.,Harris, Richard R.,Kerr, Janet S.,Green, Alicia M.,Pinto, Donald J.,et al.. "Synthesis, Chemical, and Biological Properties of Vinylogous Hydroxamic Acids: Dual Inhibitors of 5-Lipoxygenase and IL-1 Biosynthesis". . p. 4061 - 4068. Retrieved 2007/10/02.