4-(N-benzylacetamino)-3-(4-biphenylyl)-2-[N-(5-aminopentyl)-N-methylamino]-3,4-dihydroquinazoline

Base Information

Chemical Name:4-(N-benzylacetamino)-3-(4-biphenylyl)-2-[N-(5-aminopentyl)-N-methylamino]-3,4-dihydroquinazoline
CAS No.:1076689-73-0
Molecular Formula:C₃₅H₃₉N₅O
Molecular Weight:545.728
Hs Code.:

Synonyms:4-(N-benzylacetamino)-3-(4-biphenylyl)-2-[N-(5-aminopentyl)-N-methylamino]-3,4-dihydroquinazoline

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Chemical Property of 4-(N-benzylacetamino)-3-(4-biphenylyl)-2-[N-(5-aminopentyl)-N-methylamino]-3,4-dihydroquinazoline

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Technology Process of 4-(N-benzylacetamino)-3-(4-biphenylyl)-2-[N-(5-aminopentyl)-N-methylamino]-3,4-dihydroquinazoline

There total 13 articles about 4-(N-benzylacetamino)-3-(4-biphenylyl)-2-[N-(5-aminopentyl)-N-methylamino]-3,4-dihydroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: N-benzyl-3-(biphenyl-4-yl)-2-[(5-N',N'-dibenzylaminopentyl)-N''-methylamino]-3,4-dihydroquinazolin-4-ylacetamide

: 1076689-73-0
4-(N-benzylacetamino)-3-(4-biphenylyl)-2-[N-(5-aminopentyl)-N-methylamino]-3,4-dihydroquinazoline

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; for 24h;

Reference yield:

: 51644-96-3
5-tert-butoxycarbonylamino-1-aminopentane

: 1076689-73-0
4-(N-benzylacetamino)-3-(4-biphenylyl)-2-[N-(5-aminopentyl)-N-methylamino]-3,4-dihydroquinazoline

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / dichloromethane / 12 h / 20 - 40 °C

2.1: lithium aluminium tetrahydride / 2,3-dihydro-2H-furan / 12 h / 20 - 70 °C

2.2: 8 h / 20 °C

3.1: toluene / 2 h

4.1: lithium hydroxide; water / 2,3-dihydro-2H-furan / 2 h / 70 °C

4.2: pH 3 - 4

5.1: benzotriazol-1-ol / tetrahydrofuran; dichloromethane / 1 h / 0 °C

5.2: 12 h / 20 °C

6.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h

With lithium hydroxide; lithium aluminium tetrahydride; water; hydrogen; sodium carbonate; benzotriazol-1-ol; palladium 10% on activated carbon; In tetrahydrofuran; 2,3-dihydro-2H-furan; methanol; dichloromethane; toluene;

Reference yield:

: 1076689-75-2
2-[N-(5-aminopentyl)-N-methylamino]-3-(4-biphenylyl)-4-methoxycarbonylmethyl-3,4-dihydroquinazoline

: 100-46-9
benzylamine

: 1076689-73-0
4-(N-benzylacetamino)-3-(4-biphenylyl)-2-[N-(5-aminopentyl)-N-methylamino]-3,4-dihydroquinazoline

Guidance literature:: With 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; In neat (no solvent); at 40 ℃; for 12h;
DOI:10.1016/j.bmcl.2017.01.068