2-[N-(5-aminopentyl)-N-methylamino]-3-(4-biphenylyl)-4-methoxycarbonylmethyl-3,4-dihydroquinazoline

Base Information

Chemical Name:2-[N-(5-aminopentyl)-N-methylamino]-3-(4-biphenylyl)-4-methoxycarbonylmethyl-3,4-dihydroquinazoline
CAS No.:1076689-75-2
Molecular Formula:C₂₉H₃₄N₄O₂
Molecular Weight:470.615
Hs Code.:

Synonyms:2-[N-(5-aminopentyl)-N-methylamino]-3-(4-biphenylyl)-4-methoxycarbonylmethyl-3,4-dihydroquinazoline

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Chemical Property of 2-[N-(5-aminopentyl)-N-methylamino]-3-(4-biphenylyl)-4-methoxycarbonylmethyl-3,4-dihydroquinazoline

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Technology Process of 2-[N-(5-aminopentyl)-N-methylamino]-3-(4-biphenylyl)-4-methoxycarbonylmethyl-3,4-dihydroquinazoline

There total 10 articles about 2-[N-(5-aminopentyl)-N-methylamino]-3-(4-biphenylyl)-4-methoxycarbonylmethyl-3,4-dihydroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 955009-86-6
3-biphenyl-4-yl-2-[(5-N,N-dibenzylaminopentyl)-N'-methylamino]-4-methoxycarbonylmethyl-3,4-dihydroquinazoline

: 1076689-75-2
2-[N-(5-aminopentyl)-N-methylamino]-3-(4-biphenylyl)-4-methoxycarbonylmethyl-3,4-dihydroquinazoline

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; for 24h;

Reference yield:

: 51644-96-3
5-tert-butoxycarbonylamino-1-aminopentane

: 1076689-75-2
2-[N-(5-aminopentyl)-N-methylamino]-3-(4-biphenylyl)-4-methoxycarbonylmethyl-3,4-dihydroquinazoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / dichloromethane / 12 h / 20 - 40 °C

2.1: lithium aluminium tetrahydride / 2,3-dihydro-2H-furan / 12 h / 20 - 70 °C

2.2: 8 h / 20 °C

3.1: toluene / 2 h

4.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h

With lithium aluminium tetrahydride; hydrogen; sodium carbonate; palladium 10% on activated carbon; In 2,3-dihydro-2H-furan; methanol; dichloromethane; toluene;

Reference yield:

: tert-butyl 5-(N,N-dibenzylamino)pentylcarbamate

: 1076689-75-2
2-[N-(5-aminopentyl)-N-methylamino]-3-(4-biphenylyl)-4-methoxycarbonylmethyl-3,4-dihydroquinazoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / 2,3-dihydro-2H-furan / 12 h / 20 - 70 °C

1.2: 8 h / 20 °C

2.1: toluene / 2 h

3.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h

With lithium aluminium tetrahydride; hydrogen; palladium 10% on activated carbon; In 2,3-dihydro-2H-furan; methanol; toluene;