(R)-N,N-dimethyl-3-(2-methyl-(4-acetoxyphenyl)oxy)-3-phenyl-1-aminopropane

Base Information

Chemical Name:(R)-N,N-dimethyl-3-(2-methyl-(4-acetoxyphenyl)oxy)-3-phenyl-1-aminopropane
CAS No.:1270016-49-3
Molecular Formula:C₂₀H₂₅NO₃
Molecular Weight:327.423
Hs Code.:

Synonyms:(R)-N,N-dimethyl-3-(2-methyl-(4-acetoxyphenyl)oxy)-3-phenyl-1-aminopropane

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Chemical Property of (R)-N,N-dimethyl-3-(2-methyl-(4-acetoxyphenyl)oxy)-3-phenyl-1-aminopropane

Chemical Property:

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Technology Process of (R)-N,N-dimethyl-3-(2-methyl-(4-acetoxyphenyl)oxy)-3-phenyl-1-aminopropane

There total 5 articles about (R)-N,N-dimethyl-3-(2-methyl-(4-acetoxyphenyl)oxy)-3-phenyl-1-aminopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1270016-47-1
(R)-N,N-dimetyl-3-(2-methyl-(4-acetylphenyl)oxy)-3-phenyl-1-aminopropane oxalate

: 1270016-49-3
(R)-N,N-dimethyl-3-(2-methyl-(4-acetoxyphenyl)oxy)-3-phenyl-1-aminopropane

Guidance literature:: (R)-N,N-dimetyl-3-(2-methyl-(4-acetylphenyl)oxy)-3-phenyl-1-aminopropane oxalate; With acetic acid; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 25 - 35 ℃; for 12h;

With potassium carbonate; In tert-butyl methyl ether;

Reference yield:

: 100306-34-1,125712-82-5
3-chloro-1-phenylpropanol

: 1270016-49-3
(R)-N,N-dimethyl-3-(2-methyl-(4-acetoxyphenyl)oxy)-3-phenyl-1-aminopropane

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium iodide / ethanol / 7 h / 55 - 60 °C

1.2: pH 11 - 12

1.3: 2.5 h / 20 - 25 °C

2.1: sodium hydroxide / toluene; water / pH 11 - 12

3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 4.5 h / 0 - 35 °C / Inert atmosphere

3.2: 10.5 h / Inert atmosphere

3.3: 12.5 h / 25 - 35 °C

4.1: 3-chloro-benzenecarboperoxoic acid; acetic acid / dichloromethane / 12 h / 25 - 35 °C

With oxalyl dichloride; acetic acid; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; potassium iodide; sodium hydroxide; In ethanol; dichloromethane; water; toluene;

Reference yield:

: 873436-53-4
(S)-3-(dimethylamino)-1-phenylpropan-1-ol oxalate

: 1270016-49-3
(R)-N,N-dimethyl-3-(2-methyl-(4-acetoxyphenyl)oxy)-3-phenyl-1-aminopropane

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / toluene; water / pH 11 - 12

2.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 4.5 h / 0 - 35 °C / Inert atmosphere

2.2: 10.5 h / Inert atmosphere

2.3: 12.5 h / 25 - 35 °C

3.1: 3-chloro-benzenecarboperoxoic acid; acetic acid / dichloromethane / 12 h / 25 - 35 °C

With oxalyl dichloride; acetic acid; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In dichloromethane; water; toluene;