2-(6-(4-(2-hydroxyethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl acetate

Base Information

Chemical Name:2-(6-(4-(2-hydroxyethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl acetate
CAS No.:1181691-15-5
Molecular Formula:C₂₁H₂₃NO₄
Molecular Weight:353.418
Hs Code.:

Synonyms:2-(6-(4-(2-hydroxyethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl acetate

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Chemical Property of 2-(6-(4-(2-hydroxyethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl acetate

Chemical Property:

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Technology Process of 2-(6-(4-(2-hydroxyethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl acetate

There total 6 articles about 2-(6-(4-(2-hydroxyethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1181691-14-4
2-(6-(4-(2-(tert-butyldimethylsilyloxy)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl acetate

: 1181691-15-5
2-(6-(4-(2-hydroxyethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl acetate

Guidance literature:: 2-(6-(4-(2-(tert-butyldimethylsilyloxy)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl acetate; With water; hydrogen bromide; In tetrahydrofuran; at 20 ℃; for 1.5h;

With sodium hydrogencarbonate; In tetrahydrofuran; water;

Reference yield:

: 215798-19-9
6-bromo-1,2,3,4-tetrahydroisoquinolinehydrochloride

: 1181691-15-5
2-(6-(4-(2-hydroxyethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl acetate

Guidance literature:: Multi-step reaction with 6 steps

1: (R)-2-hydroxy-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone hydrochloride / dichloromethane / 0.5 h / 20 °C

2: sodium hydrogencarbonate / ethanol; benzene / 3 h / 100 °C / Inert atmosphere; Microwave irradiation

3: methanol; sodium hydroxide / 0.33 h

4: triethylamine / dichloromethane / 20 °C

5: triethylamine / dichloromethane / 0.5 h / 20 °C

6: water; hydrogen bromide / tetrahydrofuran / 1.5 h / 20 °C

With methanol; (R)-2-hydroxy-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone hydrochloride; water; hydrogen bromide; sodium hydrogencarbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; benzene; 2: Suzuki Coupling;

Reference yield:

: 1181691-11-1
2-hydroxy-1-(6-(4-(2-hydroxyethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

: 1181691-15-5
2-(6-(4-(2-hydroxyethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: methanol; sodium hydroxide / 0.33 h

2: triethylamine / dichloromethane / 20 °C

3: triethylamine / dichloromethane / 0.5 h / 20 °C

4: water; hydrogen bromide / tetrahydrofuran / 1.5 h / 20 °C

With methanol; water; hydrogen bromide; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane;