3-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propyl ethylcarbamate

Base Information

Chemical Name:3-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propyl ethylcarbamate
CAS No.:1361318-60-6
Molecular Formula:C₂₆H₂₆ClF₆N₅O₅
Molecular Weight:637.966
Hs Code.:

3-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propyl ethylcarbamate

Synonyms:3-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propyl ethylcarbamate

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Chemical Property of 3-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propyl ethylcarbamate

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Technology Process of 3-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propyl ethylcarbamate

There total 9 articles about 3-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propyl ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 959140-61-5
{3-(4-chlorophenyl)-5-oxo-4-[(2,S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid

: 1361319-30-3
3-amino-2-[3-(trifluoromethyl)phenyl]propyl ethylcarbamate hydrochloride

: 1361318-59-3
3-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propyl ethylcarbamate

: 1361318-60-6
3-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propyl ethylcarbamate

Guidance literature:: {3-(4-chlorophenyl)-5-oxo-4-[(2,S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

3-amino-2-[3-(trifluoromethyl)phenyl]propyl ethylcarbamate hydrochloride; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 0.5h;

Reference yield:

: 62451-84-7
(3-trifluoromethyl-phenyl)-acetic acid methyl ester

: 1361318-59-3
3-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propyl ethylcarbamate

: 1361318-60-6
3-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propyl ethylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium; diisopropylamine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran; hexane / 0.33 h / -78 °C

1.2: -78 - 20 °C

2.1: water; sodium tetrahydroborate / isopropyl alcohol

2.2: 80 °C / pH 5

3.1: sodium hydrogencarbonate / acetonitrile; water / 20 °C

4.1: dmap; pyridine / 20 - 50 °C

5.1: hydrogenchloride / 1,4-dioxane / 2 h / 60 °C

6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.08 h / 20 °C

6.2: 0.5 h / 20 °C

With pyridine; hydrogenchloride; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium tetrahydroborate; n-butyllithium; water; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; hexane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 1361319-26-7
methyl 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-[3-(trifluoromethyl)phenyl]propanoate

: 1361318-59-3
3-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propyl ethylcarbamate

: 1361318-60-6
3-[({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[3-(trifluoromethyl)phenyl]propyl ethylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; sodium tetrahydroborate / isopropyl alcohol

1.2: 80 °C / pH 5

2.1: sodium hydrogencarbonate / acetonitrile; water / 20 °C

3.1: dmap; pyridine / 20 - 50 °C

4.1: hydrogenchloride / 1,4-dioxane / 2 h / 60 °C

5.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.08 h / 20 °C

5.2: 0.5 h / 20 °C

With pyridine; hydrogenchloride; dmap; sodium tetrahydroborate; water; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;