Chemical Property of Perphenazine
Chemical Property:
- Appearance/Colour:Off-white to pale yellow solid
- Melting Point:35339ºC
- Refractive Index:1.6100 (estimate)
- Boiling Point:580.4 °C at 760 mmHg
- PKA:pKa 7.8(H2O,t =24±1) (Uncertain)
- Flash Point:304.8 °C
- PSA：55.25000
- Density:1.253 g/cm3
- LogP:3.88350
- Storage Temp.:2-8°C
- Solubility.:Practically insoluble in water, freely soluble in methylene chloride, soluble in ethanol (96 per cent). It dissolves in dilute solutions of hydrochloric acid.
- Water Solubility.:28.28mg/L(24 oC)
- XLogP3:4.2
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:6
- Exact Mass:403.1485113
- Heavy Atom Count:27
- Complexity:463
- Purity/Quality:
-
99%, *data from raw suppliers
Perphenazine
*data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
22-43
- Safety Statements:
28-36/37/39-45
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Drug Classes:Antipsychotic Agents
- Canonical SMILES:C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO
- Recent ClinicalTrials:Recommendations of Enhanced Recovery Interventions for Patient's Clinical Team and Collection of Associated Data
- Recent EU Clinical Trials:English: Are Antipsychotics Neurotoxic or Neuroprotective? A Randomised Multicentre Longitudinal Study for Comparison of Two Therapy Strategies for the Treatment of Schizophrenia.
- Recent NIPH Clinical Trials:An intervention study of optimizing algorism-based pharmacological treatment for schizophrenia
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Description
Perphenazine (58-39-9) is a clinically useful typical antipsychotic drug. The therapeutic mode of action is not well understood but it binds to a wide variety of receptors including serotonin, histamine, dopamine, and α-adrenergic.1 Perphenazine is an inhibitor of acid sphingomyelinase(ASM)2 and positively affected xenografted tumor growth via perturbation of intracellular cholesterol transport through ASM3. It has also been shown to be an inhibitor of glutamate dehydrogenase.4
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Uses
D2 dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic. Inhibits glutamate dehydrogenase in vitro. Antipsychotic.
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Therapeutic Function
Tranquilizer
