2-Pyrimidinamine, 4,5-dimethyl- (9CI)

Base Information

• Chemical Name: 2-Pyrimidinamine, 4,5-dimethyl- (9CI)
• CAS No.: 1193-74-4
• Molecular Formula: C₆H₉N₃
• Molecular Weight: 123.158
• Hs Code.: 2933599090
• Mol file: 1193-74-4.mol

Synonyms:Pyrimidine,2-amino-4,5-dimethyl- (7CI,8CI); 2-Amino-4,5-dimethylpyrimidine;4,5-dimethyl-2-pyrimidinamine; NSC 27188

Chemical Property of 2-Pyrimidinamine, 4,5-dimethyl- (9CI)

Chemical Property:

• Vapor Pressure: 0.00102mmHg at 25°C
• Melting Point: 215.8°C
• Refractive Index: 1.5589 (estimate)
• Boiling Point: 301.9°Cat760mmHg
• Flash Point: 161.7°C
• PSA: 51.80000
• Density: 1.112g/cm³
• LogP: 1.25680
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4,5-Dimethylpyrimidin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyrimidinamine, 4,5-dimethyl- (9CI)

There total 10 articles about 2-Pyrimidinamine, 4,5-dimethyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-amino-4-chloro-5,6-dimethyl-pyrimidine (14394-61-7) → 4,5-dimethylpyrimidin-2-amine (1193-74-4)

Guidance literature:

With ammonia; hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 18h; under 760.051 Torr;

Reference yield: 52.0%

guanidine hydrochloride (50-01-1) + 3-chloro-2-methyl-2-butenal (1679-40-9) → 4,5-dimethylpyrimidin-2-amine (1193-74-4)

Guidance literature:

With potassium carbonate; In methanol; Reflux;

DOI:10.1002/ejoc.201700737

Reference yield:

2,4-dichloro-5,6-dimethylpyrimidine (1780-32-1) → 4,5-dimethylpyrimidin-2-amine (1193-74-4)

Guidance literature:

Multi-step reaction with 2 steps

1: alcohol; ammonia / 100 °C / im Rohr

2: zinc dust; water

With ethanol; ammonia; water; zinc;

upstream raw materials:

2-amino-4-chloro-5,6-dimethyl-pyrimidine

1-methoxy-2-methyl-1-buten-3-one

guanidine nitrate

diguanidine carbonate

Downstream raw materials:

N-acetyl-sulfanilic acid-(4,5-dimethyl-pyrimidin-2-ylamide)

2-sulfanilamido-4,5-dimethylpyrimidine

Refernces

• 1、 -. "Α 7 as intranuclear hydroxynicotinic acetylcholine receptor quinuclidines compd.". Paragraph 0305; 0306. . Retrieved 2018/10/03.
• 2、 -. "QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS". Page/Page column 90-91. . Retrieved 2009/10/31.