rel-(1R,2S)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenylbutane

Base Information

• Chemical Name: rel-(1R,2S)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenylbutane
• CAS No.: 109640-22-4
• Molecular Formula: C₃₁H₂₄ClF₇O₂
• Molecular Weight: 596.972
• Mol file: 109640-22-4.mol

Synonyms:rel-(1R,2S)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenylbutane

Chemical Property of rel-(1R,2S)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenylbutane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rel-(1R,2S)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenylbutane

There total 1 articles about rel-(1R,2S)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenylbutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(E)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenyl-1-butene (103628-15-5) → rel-(1R,2S)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenylbutane (109640-22-4)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In ethanol; at 80 ℃; for 4.5h;

DOI:10.1021/jm00393a014

Reference yield:

rel-(1R,2S)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenylbutane (109640-22-4) → rel-(1R,2R)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-(4-hydroxyphenyl)-2-phenylbutane (109669-15-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 72 h / Heating

2: NaOMe / dimethylformamide / 2 h / 40 °C

With sodium methylate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00393a014

Reference yield:

dimethyl amine (124-40-3) + rel-(1R,2S)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenylbutane (109640-22-4) → Dimethyl-[2-(4-{(1R,2S)-2-phenyl-1-[4-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenoxy)-phenyl]-butyl}-phenoxy)-ethyl]-amine (109640-24-6)

Guidance literature:

In ethanol; for 72h; Heating;

DOI:10.1021/jm00393a014

upstream raw materials:

(E)-1-<4-(2-chloroethoxy)phenyl>-1-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-2-phenyl-1-butene

Downstream raw materials:

Dimethyl-[2-(4-{(1R,2S)-2-phenyl-1-[4-(2,3,5,6-tetrafluoro-4-trifluoromethyl-phenoxy)-phenyl]-butyl}-phenoxy)-ethyl]-amine

rel-(1R,2R)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-(4-hydroxyphenyl)-2-phenylbutane