N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-cyclohexylthiourea

Base Information

• Chemical Name: N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-cyclohexylthiourea
• CAS No.: 947748-47-2
• Molecular Formula: C₂₁H₃₂N₂O₃S₂
• Molecular Weight: 424.629
• Mol file: 947748-47-2.mol

Synonyms:N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-cyclohexylthiourea

Chemical Property of N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-cyclohexylthiourea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-cyclohexylthiourea

There total 1 articles about N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-cyclohexylthiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride (112160-39-1) → N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-cyclohexylthiourea (947748-47-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 100 percent / NH₃ / CH₂Cl₂ / 0.33 h / 0 °C

2.1: KOH / benzene / 24 h / Heating

2.2: 75 percent / COCl₂ / toluene / 0 - 20 °C

3.1: 94 percent / CH₂Cl₂ / 0.5 h / 20 °C

With potassium hydroxide; ammonia; In dichloromethane; benzene;

DOI:10.1055/s-2007-983706

Reference yield: 74.0%

N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-cyclohexylthiourea (947748-47-2) + N-benzyloxyamine (622-33-3) → N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-cyclohexyl-N''-benzyloxyguanidine (947748-61-0)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1055/s-2007-983706

Reference yield: 65.0%

N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-cyclohexylthiourea (947748-47-2) + trans-4-{[(4-methylphenyl)diphenylmethyl]amino}-N-(fluoren-9-ylmethyloxycarbonyl)-L-proline (1061737-21-0) + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine (35661-39-3,136132-75-7) + trifluoroacetic acid (76-05-1) → 2C2HF3O2*C18H32N6O4

Guidance literature:

Multistep reaction.;

DOI:10.1021/jo8012258

upstream raw materials:

2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride

Downstream raw materials:

N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-cyclohexyl-N''-benzyloxyguanidine