(S)-2-[4-(Benzyloxycarbonyl-methyl-amino)-benzoylamino]-4-methylcarbamoyl-butyric acid benzyl ester

Base Information

Chemical Name:(S)-2-[4-(Benzyloxycarbonyl-methyl-amino)-benzoylamino]-4-methylcarbamoyl-butyric acid benzyl ester
CAS No.:79974-05-3
Molecular Formula:C₂₉H₃₁N₃O₆
Molecular Weight:517.582
Hs Code.:

Synonyms:(S)-2-[4-(Benzyloxycarbonyl-methyl-amino)-benzoylamino]-4-methylcarbamoyl-butyric acid benzyl ester

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Chemical Property of (S)-2-[4-(Benzyloxycarbonyl-methyl-amino)-benzoylamino]-4-methylcarbamoyl-butyric acid benzyl ester

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Technology Process of (S)-2-[4-(Benzyloxycarbonyl-methyl-amino)-benzoylamino]-4-methylcarbamoyl-butyric acid benzyl ester

There total 7 articles about (S)-2-[4-(Benzyloxycarbonyl-methyl-amino)-benzoylamino]-4-methylcarbamoyl-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-2-[4-(Benzyloxycarbonyl-methyl-amino)-benzoylamino]-5-isobutoxycarbonyloxy-5-oxo-pentanoic acid benzyl ester

: 74-89-5
methylamine

: 79974-05-3
(S)-2-[4-(Benzyloxycarbonyl-methyl-amino)-benzoylamino]-4-methylcarbamoyl-butyric acid benzyl ester

Guidance literature:: With triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide; at 25 ℃; for 2h; Yield given;
DOI:10.1021/jm00344a018

Reference yield:

: 10541-83-0,937737-33-2
N-methyl-p-aminobenzoic acid

: 79974-05-3
(S)-2-[4-(Benzyloxycarbonyl-methyl-amino)-benzoylamino]-4-methylcarbamoyl-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / 2 N NaOH / dioxane; H₂O / 0.5 h / 0 - 5 °C

2: 99 percent / SOCl₂ / benzene / 2 h / Heating

3: 89 percent / (i-Pr)2NEt / dioxane; H₂O

4: Et₃N / dimethylformamide; dioxane / 1 h / -10 °C

5: Et₃N / dimethylformamide; dioxane / 2 h / 25 °C

With sodium hydroxide; thionyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00344a018

Reference yield:

: 13030-09-6
1-benzyl L-glutamate

: 79974-05-3
(S)-2-[4-(Benzyloxycarbonyl-methyl-amino)-benzoylamino]-4-methylcarbamoyl-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / (i-Pr)2NEt / dioxane; H₂O

2: Et₃N / dimethylformamide; dioxane / 1 h / -10 °C

3: Et₃N / dimethylformamide; dioxane / 2 h / 25 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00344a018