1-{4-[2(6-morpholin-4-ylpyridin-3-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutanamine

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Chemical Name:1-{4-[2(6-morpholin-4-ylpyridin-3-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutanamine
CAS No.:1374261-24-1
Molecular Formula:C₃₃H₃₁N₇O
Molecular Weight:541.655
Hs Code.:

Synonyms:1-{4-[2(6-morpholin-4-ylpyridin-3-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutanamine

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Chemical Property of 1-{4-[2(6-morpholin-4-ylpyridin-3-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutanamine

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Technology Process of 1-{4-[2(6-morpholin-4-ylpyridin-3-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutanamine

There total 7 articles about 1-{4-[2(6-morpholin-4-ylpyridin-3-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 485799-04-0
4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]morpholine

: 1374260-87-3
tert-butyl {1-[4-(2-bromo-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate

: 1374261-24-1
1-{4-[2(6-morpholin-4-ylpyridin-3-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutanamine

Guidance literature:: 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]morpholine; tert-butyl {1-[4-(2-bromo-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate; With potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In methanol; water; N,N-dimethyl-formamide; at 160 ℃; for 1h; Microwave irradiation;

With hydrogenchloride; In methanol; water; for 24h;

Reference yield:

: 1374260-84-0
tert-butyl {1-[4-(9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate

: 1374261-24-1
1-{4-[2(6-morpholin-4-ylpyridin-3-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridinium perbromide hydrobromide / tetrahydrofuran / -78 - 20 °C

2.1: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / methanol; water; N,N-dimethyl-formamide / 1 h / 160 °C / Microwave irradiation

2.2: 24 h

With potassium phosphate; pyridinium perbromide hydrobromide; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 885-70-1
5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one

: 1374261-24-1
1-{4-[2(6-morpholin-4-ylpyridin-3-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutanamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: Lawessons reagent; pyridine / 18 h / 100 °C

2.1: 1 h / 95 °C

3.1: acetic acid / 13 h / 105 °C

4.1: N-Bromosuccinimide / tetrahydrofuran / 2 h / 0 - 20 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 15 h / Reflux

6.1: pyridinium perbromide hydrobromide / tetrahydrofuran / -78 - 20 °C

7.1: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / methanol; water; N,N-dimethyl-formamide / 1 h / 160 °C / Microwave irradiation

7.2: 24 h

With Lawessons reagent; pyridine; potassium phosphate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; pyridinium perbromide hydrobromide; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; toluene;