(R)-(-)-Methyl 2-hydroxy-4-phenyl-4-pentenoate

Base Information

• Chemical Name: (R)-(-)-Methyl 2-hydroxy-4-phenyl-4-pentenoate
• CAS No.: 119072-58-1
• Molecular Formula: C₁₂H₁₄O₃
• Molecular Weight: 206.241
• Mol file: 119072-58-1.mol

Synonyms:(R)-(-)-Methyl 2-hydroxy-4-phenyl-4-pentenoate

Chemical Property of (R)-(-)-Methyl 2-hydroxy-4-phenyl-4-pentenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(-)-Methyl 2-hydroxy-4-phenyl-4-pentenoate

There total 2 articles about (R)-(-)-Methyl 2-hydroxy-4-phenyl-4-pentenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Methyl glyoxylate (922-68-9) + isopropenylbenzene (98-83-9,6144-04-3,25014-31-7,42612-14-6) → (R)-(-)-Methyl 2-hydroxy-4-phenyl-4-pentenoate (119072-58-1)

Guidance literature:

With titanium(IV) dichlorodiisopropylate; 4 A molecular sieve; (R)-1,1'-Bi-2-naphthol; In dichloromethane; at -30 ℃; for 8h; Product distribution; other olefins, other titanium complexes with var. chiral alkoxy ligands; reactivity, enantioselectivity, E selectivity, and regioselectivity of asymmetric ene reactions;

Reference yield:

Methyl glyoxylate (922-68-9) + isopropenylbenzene (98-83-9,6144-04-3,25014-31-7,42612-14-6) → (R)-(-)-Methyl 2-hydroxy-4-phenyl-4-pentenoate (119072-58-1) + methyl (2R)-2-hydroxy-4-phenyl-4-pentenoate (126754-60-7)

Guidance literature:

With titanium(IV) dichlorodiisopropylate; 4 A molecular sieve; (R)-1,1'-Bi-2-naphthol; In dichloromethane; at -30 ℃; for 3h; Product distribution; Mechanism; other diisopropoxytitanium halide, other (partially resolved, 13-66.8 percent e.e.) (R)-1,1'-bi-2-naphthol, other temperature;

DOI:10.1016/0040-4020(92)80018-B

Reference yield:

(R)-(-)-Methyl 2-hydroxy-4-phenyl-4-pentenoate (119072-58-1) + methyl iodide (74-88-4) → (R)-methyl 2-methoxy-4-phenyl-4-pentenoate (126754-68-5)

Guidance literature:

With silver(l) oxide; In diethyl ether; at 20 ℃; for 24h;

DOI:10.15227/orgsyn.071.0014

upstream raw materials:

Methyl glyoxylate

isopropenylbenzene

Downstream raw materials:

(R)-methyl 2-methoxy-4-phenyl-4-pentenoate