(R)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]-2-methylisoquinoline

Base Information

• Chemical Name: (R)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]-2-methylisoquinoline
• CAS No.: 67596-84-3
• Molecular Formula: C18H25NO
• Molecular Weight: 271.403
• Mol file: 67596-84-3.mol

Synonyms:(R)-1-(4-Methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline;Isoquinoline,1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]-,(1R);(R)-1-(4-Methoxy-benzyl)-1,2,3,4,5,6,7,8-octahydro-isochinolin;Isoquinoline,1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]-,(R);(R)-1,2,3,4,5,6,7,8-Octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline;(R)-1-(4-Methoxy-benzyl)-2-methyl-1,2,3,4,5,6,7,8-octahydro-isochinolin;Isoquinoline,1,2,3,4,5,6,7,8-octahydro-1-(p-methoxybenzyl)-,(+)-(8CI);

Chemical Property of (R)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]-2-methylisoquinoline

Chemical Property:

• Vapor Pressure: 1.55E-06mmHg at 25°C
• Boiling Point: 397.8°C at 760 mmHg
• PKA: 9.03±0.40(Predicted)
• Flash Point: 117°C
• PSA: 12.47000
• Density: 1.06g/cm³
• LogP: 3.75030

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]-2-methylisoquinoline

There total 6 articles about (R)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]-2-methylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline (30356-08-2,57849-23-7) → (+)-2-methyl-1-(4-methoxy)benzyl-1,2,3,4,5,6,7,8-hexahydroisoquinoline (67596-84-3,31414-58-1)

Guidance literature:

formaldehyd; (S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline; With methanol; for 0.25h;

With sodium tetrahydroborate; at 20 ℃; for 10h; Reagent/catalyst;

Reference yield:

4-Methoxyphenylacetic acid (104-01-8) → (+)-2-methyl-1-(4-methoxy)benzyl-1,2,3,4,5,6,7,8-hexahydroisoquinoline (67596-84-3,31414-58-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: diisopropyl-carbodiimide; dmap / dichloromethane / 10 h / 0 - 20 °C

2.1: trichlorophosphate / toluene / 4 h / Reflux

3.1: phenylsilane; pyrrolidine / tetrahydrofuran; methanol / 5 h / 20 °C / Inert atmosphere

4.1: methanol / 0.25 h

4.2: 10 h / 20 °C

With pyrrolidine; methanol; dmap; phenylsilane; diisopropyl-carbodiimide; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

2-(1-cyclohexenyl)ethylamine (3399-73-3) → (+)-2-methyl-1-(4-methoxy)benzyl-1,2,3,4,5,6,7,8-hexahydroisoquinoline (67596-84-3,31414-58-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: diisopropyl-carbodiimide; dmap / dichloromethane / 10 h / 0 - 20 °C

2.1: trichlorophosphate / toluene / 4 h / Reflux

3.1: phenylsilane; pyrrolidine / tetrahydrofuran; methanol / 5 h / 20 °C / Inert atmosphere

4.1: methanol / 0.25 h

4.2: 10 h / 20 °C

With pyrrolidine; methanol; dmap; phenylsilane; diisopropyl-carbodiimide; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; toluene;

upstream raw materials:

1-(p-methoxybenzyl)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline

formaldehyd

(S)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline

4-Methoxyphenylacetic acid

Downstream raw materials:

Levorphanol

dextromethorphan