2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}-N-[(E)-pyrrolidin-1-ylmethylidene]aniline

Base Information

Chemical Name:2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}-N-[(E)-pyrrolidin-1-ylmethylidene]aniline
CAS No.:1421920-95-7
Molecular Formula:C₂₄H₂₇N₃S
Molecular Weight:389.564
Hs Code.:

Synonyms:2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}-N-[(E)-pyrrolidin-1-ylmethylidene]aniline

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Chemical Property of 2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}-N-[(E)-pyrrolidin-1-ylmethylidene]aniline

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Technology Process of 2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}-N-[(E)-pyrrolidin-1-ylmethylidene]aniline

There total 5 articles about 2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}-N-[(E)-pyrrolidin-1-ylmethylidene]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123-75-1
pyrrolidine

: 1421922-08-8
2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}aniline hydrobromide

: 122-51-0
orthoformic acid triethyl ester

: 1421920-95-7
2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}-N-[(E)-pyrrolidin-1-ylmethylidene]aniline

Guidance literature:: 2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}aniline hydrobromide; orthoformic acid triethyl ester; With camphor-10-sulfonic acid; at 100 ℃; for 2.5h;

pyrrolidine; In chloroform; at 20 ℃; for 80h;

Reference yield:

: 1421922-04-4
2-(2,5-dimethyl-4-nitrophenyl)ethanethioamide

: 1421920-95-7
2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}-N-[(E)-pyrrolidin-1-ylmethylidene]aniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropyl alcohol / 1 h / 80 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 19 h / 20 °C

3.1: camphor-10-sulfonic acid / 2.5 h / 100 °C

3.2: 80 h / 20 °C

With palladium 10% on activated carbon; camphor-10-sulfonic acid; hydrogen; In methanol; isopropyl alcohol;

Reference yield:

: 1421922-07-7
2-(2,5-dimethyl-4-nitrobenzyl)-4-(4-methylphenyl)-1,3-thiazole hydrobromide

: 1421920-95-7
2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}-N-[(E)-pyrrolidin-1-ylmethylidene]aniline

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 19 h / 20 °C

2.1: camphor-10-sulfonic acid / 2.5 h / 100 °C

2.2: 80 h / 20 °C

With palladium 10% on activated carbon; camphor-10-sulfonic acid; hydrogen; In methanol;