2-(2,5-dimethyl-4-nitrobenzyl)-4-(4-methylphenyl)-1,3-thiazole hydrobromide

Base Information

• Chemical Name: 2-(2,5-dimethyl-4-nitrobenzyl)-4-(4-methylphenyl)-1,3-thiazole hydrobromide
• CAS No.: 1421922-07-7
• Molecular Formula: BrH*C₁₉H₁₈N₂O₂S
• Molecular Weight: 419.342
• Mol file: 1421922-07-7.mol

Synonyms:2-(2,5-dimethyl-4-nitrobenzyl)-4-(4-methylphenyl)-1,3-thiazole hydrobromide

Chemical Property of 2-(2,5-dimethyl-4-nitrobenzyl)-4-(4-methylphenyl)-1,3-thiazole hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,5-dimethyl-4-nitrobenzyl)-4-(4-methylphenyl)-1,3-thiazole hydrobromide

There total 3 articles about 2-(2,5-dimethyl-4-nitrobenzyl)-4-(4-methylphenyl)-1,3-thiazole hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2,5-dimethyl-4-nitrophenyl)ethanethioamide (1421922-04-4) + 4-(bromoacetyl)toluene (619-41-0) → 2-(2,5-dimethyl-4-nitrobenzyl)-4-(4-methylphenyl)-1,3-thiazole hydrobromide (1421922-07-7)

Guidance literature:

In isopropyl alcohol; at 80 ℃; for 1h; Inert atmosphere;

Reference yield:

(2,5-dimethylphenyl)acetonitrile (16213-85-7) → 2-(2,5-dimethyl-4-nitrobenzyl)-4-(4-methylphenyl)-1,3-thiazole hydrobromide (1421922-07-7)

Guidance literature:

Multi-step reaction with 3 steps

1: nitric acid / 0.5 h / Cooling with ice

2: hydrogenchloride; O,O-Diethyl hydrogen phosphorodithioate / ethyl acetate / 24 h / 20 °C

3: isopropyl alcohol / 1 h / 80 °C / Inert atmosphere

With hydrogenchloride; nitric acid; O,O-Diethyl hydrogen phosphorodithioate; In ethyl acetate; isopropyl alcohol;

Reference yield:

(2,5-dimethyl-4-nitrophenyl)acetonitrile (1421922-03-3) → 2-(2,5-dimethyl-4-nitrobenzyl)-4-(4-methylphenyl)-1,3-thiazole hydrobromide (1421922-07-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; O,O-Diethyl hydrogen phosphorodithioate / ethyl acetate / 24 h / 20 °C

2: isopropyl alcohol / 1 h / 80 °C / Inert atmosphere

With hydrogenchloride; O,O-Diethyl hydrogen phosphorodithioate; In ethyl acetate; isopropyl alcohol;

upstream raw materials:

(2,5-dimethylphenyl)acetonitrile

(2,5-dimethyl-4-nitrophenyl)acetonitrile

2-(2,5-dimethyl-4-nitrophenyl)ethanethioamide

4-(bromoacetyl)toluene

Downstream raw materials:

2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}aniline hydrobromide

tert-butyl N-{(E)-[(2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}phenyl)imino]methyl}-N-methylglycinate

methyl N-{(E)-[(2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}phenyl)imino]methyl}-N-methylglycinate

2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}-N-[(E)-pyrrolidin-1-ylmethylidene]aniline