2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}aniline hydrobromide

Base Information

• Chemical Name: 2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}aniline hydrobromide
• CAS No.: 1421922-08-8
• Molecular Formula: BrH*C₁₉H₂₀N₂S
• Molecular Weight: 389.359
• Mol file: 1421922-08-8.mol

Synonyms:2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}aniline hydrobromide

Chemical Property of 2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}aniline hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}aniline hydrobromide

There total 4 articles about 2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}aniline hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2,5-dimethyl-4-nitrobenzyl)-4-(4-methylphenyl)-1,3-thiazole hydrobromide (1421922-07-7) → 2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}aniline hydrobromide (1421922-08-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 19h;

Reference yield:

2-(2,5-dimethyl-4-nitrophenyl)ethanethioamide (1421922-04-4) → 2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}aniline hydrobromide (1421922-08-8)

Guidance literature:

Multi-step reaction with 2 steps

1: isopropyl alcohol / 1 h / 80 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 19 h / 20 °C

With palladium 10% on activated carbon; hydrogen; In methanol; isopropyl alcohol;

Reference yield:

(2,5-dimethylphenyl)acetonitrile (16213-85-7) → 2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}aniline hydrobromide (1421922-08-8)

Guidance literature:

Multi-step reaction with 4 steps

1: nitric acid / 0.5 h / Cooling with ice

2: hydrogenchloride; O,O-Diethyl hydrogen phosphorodithioate / ethyl acetate / 24 h / 20 °C

3: isopropyl alcohol / 1 h / 80 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol / 19 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; nitric acid; O,O-Diethyl hydrogen phosphorodithioate; In methanol; ethyl acetate; isopropyl alcohol;

upstream raw materials:

2-(2,5-dimethyl-4-nitrophenyl)ethanethioamide

2-(2,5-dimethyl-4-nitrobenzyl)-4-(4-methylphenyl)-1,3-thiazole hydrobromide

(2,5-dimethylphenyl)acetonitrile

(2,5-dimethyl-4-nitrophenyl)acetonitrile

Downstream raw materials:

2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}-N-[(E)-pyrrolidin-1-ylmethylidene]aniline

tert-butyl N-{(E)-[(2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}phenyl)imino]methyl}-N-methylglycinate

methyl N-{(E)-[(2,5-dimethyl-4-{[4-(4-methylphenyl)-1,3-thiazol-2-yl]methyl}phenyl)imino]methyl}-N-methylglycinate