benzyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylate

Base Information

Chemical Name:benzyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylate
CAS No.:87919-08-2
Molecular Formula:C₆₅H₉₇NO₁₇
Molecular Weight:1164.48
Hs Code.:

Synonyms:benzyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylate

Suppliers and Price of benzyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of benzyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylate

There total 6 articles about benzyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.3%

: 87919-06-0
benzyl trans-4-(aminomethyl)cyclohexanecarboxylate tosylate

: 87919-03-7
6',6''-di-tert-butyl-18β-glycyrrhizin

: 87919-08-2
benzyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylate

Guidance literature:: With diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide; 5 degC, 1 h; 12 h, r.t.;

Reference yield:

: 50867-21-5
N,N'-dicylohexylcarbamimidic acid tert-butyl ester

: 87919-08-2
benzyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 11.5 percent / CuCl / CHCl₃; dimethylformamide / 72 h / Ambient temperature

2: 76.3 percent / diethyl phosphorylcyanide, triethylamine / dimethylformamide / 5 degC, 1 h; 12 h, r.t.

With diethyl cyanophosphonate; triethylamine; copper(l) chloride; In chloroform; N,N-dimethyl-formamide;

Reference yield:

: 83896-44-0,103000-77-7,119479-05-9,142394-43-2,1405-86-3
glycyrrizhin

: 87919-08-2
benzyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 22.6 percent / CHCl₃; dimethylformamide / 72 h / Ambient temperature

2: 76.5 percent / 5percent potassium hydroxide / methanol / 4 h / Ambient temperature

3: 38 percent / CuCl, dicyclohexylcarbodiimide / CHCl₃; dimethylformamide / 72 h / Ambient temperature

4: 90 percent / hydrogen / 5percent Pd-carbon / ethyl acetate / 760 Torr

5: 76.3 percent / diethyl phosphorylcyanide, triethylamine / dimethylformamide / 5 degC, 1 h; 12 h, r.t.

With potassium hydroxide; diethyl cyanophosphonate; hydrogen; triethylamine; dicyclohexyl-carbodiimide; copper(l) chloride; palladium on activated charcoal; In methanol; chloroform; ethyl acetate; N,N-dimethyl-formamide;