Technology Process of benzyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylate
There total 6 articles about benzyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
diethyl cyanophosphonate; triethylamine;
In
N,N-dimethyl-formamide;
5 degC, 1 h; 12 h, r.t.;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 11.5 percent / CuCl / CHCl3; dimethylformamide / 72 h / Ambient temperature
2: 76.3 percent / diethyl phosphorylcyanide, triethylamine / dimethylformamide / 5 degC, 1 h; 12 h, r.t.
With
diethyl cyanophosphonate; triethylamine; copper(l) chloride;
In
chloroform; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 22.6 percent / CHCl3; dimethylformamide / 72 h / Ambient temperature
2: 76.5 percent / 5percent potassium hydroxide / methanol / 4 h / Ambient temperature
3: 38 percent / CuCl, dicyclohexylcarbodiimide / CHCl3; dimethylformamide / 72 h / Ambient temperature
4: 90 percent / hydrogen / 5percent Pd-carbon / ethyl acetate / 760 Torr
5: 76.3 percent / diethyl phosphorylcyanide, triethylamine / dimethylformamide / 5 degC, 1 h; 12 h, r.t.
With
potassium hydroxide; diethyl cyanophosphonate; hydrogen; triethylamine; dicyclohexyl-carbodiimide; copper(l) chloride;
palladium on activated charcoal;
In
methanol; chloroform; ethyl acetate; N,N-dimethyl-formamide;
