hydroxysuccinimidyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylate

Base Information

Chemical Name:hydroxysuccinimidyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylate
CAS No.:87919-12-8
Molecular Formula:C₆₂H₉₄N₂O₁₉
Molecular Weight:1171.43
Hs Code.:

Synonyms:hydroxysuccinimidyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylate

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Chemical Property of hydroxysuccinimidyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylate

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Technology Process of hydroxysuccinimidyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylate

There total 8 articles about hydroxysuccinimidyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 87919-10-6
N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylic acid

: 87919-12-8
hydroxysuccinimidyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

Reference yield:

: 50867-21-5
N,N'-dicylohexylcarbamimidic acid tert-butyl ester

: 87919-12-8
hydroxysuccinimidyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 11.5 percent / CuCl / CHCl₃; dimethylformamide / 72 h / Ambient temperature

2: 76.3 percent / diethyl phosphorylcyanide, triethylamine / dimethylformamide / 5 degC, 1 h; 12 h, r.t.

3: 75.8 percent / hydrogen / 5percent Pd-carbon / methanol; ethyl acetate / 2.5 h / 760 Torr

4: 36 percent / ethyl dimethylaminopropylcarbodiimide*HCl / dimethylformamide / 1 h / 0 °C

With diethyl cyanophosphonate; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; copper(l) chloride; palladium on activated charcoal; In methanol; chloroform; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 83896-44-0,103000-77-7,119479-05-9,142394-43-2,1405-86-3
glycyrrizhin

: 87919-12-8
hydroxysuccinimidyl N-(6',6''-di-tert-butyl-18β-glycyrrhizinyl)-trans-4-aminomethylcyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 22.6 percent / CHCl₃; dimethylformamide / 72 h / Ambient temperature

2: 76.5 percent / 5percent potassium hydroxide / methanol / 4 h / Ambient temperature

3: 38 percent / CuCl, dicyclohexylcarbodiimide / CHCl₃; dimethylformamide / 72 h / Ambient temperature

4: 90 percent / hydrogen / 5percent Pd-carbon / ethyl acetate / 760 Torr

5: 76.3 percent / diethyl phosphorylcyanide, triethylamine / dimethylformamide / 5 degC, 1 h; 12 h, r.t.

6: 75.8 percent / hydrogen / 5percent Pd-carbon / methanol; ethyl acetate / 2.5 h / 760 Torr

7: 36 percent / ethyl dimethylaminopropylcarbodiimide*HCl / dimethylformamide / 1 h / 0 °C

With potassium hydroxide; diethyl cyanophosphonate; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; copper(l) chloride; palladium on activated charcoal; In methanol; chloroform; ethyl acetate; N,N-dimethyl-formamide;