[[5-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d] isoxazol-3-yl]-(2-methoxy-ethyl)-amino]-acetic acid

Base Information

Chemical Name:[[5-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d] isoxazol-3-yl]-(2-methoxy-ethyl)-amino]-acetic acid
CAS No.:1299490-22-4
Molecular Formula:C₂₆H₂₄F₂N₂O₆
Molecular Weight:498.483
Hs Code.:

Synonyms:[[5-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d] isoxazol-3-yl]-(2-methoxy-ethyl)-amino]-acetic acid

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Chemical Property of [[5-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d] isoxazol-3-yl]-(2-methoxy-ethyl)-amino]-acetic acid

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Technology Process of [[5-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d] isoxazol-3-yl]-(2-methoxy-ethyl)-amino]-acetic acid

There total 12 articles about [[5-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d] isoxazol-3-yl]-(2-methoxy-ethyl)-amino]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1299490-29-1
[[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-(2-methoxy-ethyl)-amino]-acetic acid ethyl ester

: 1299490-22-4
[[5-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d] isoxazol-3-yl]-(2-methoxy-ethyl)-amino]-acetic acid

Guidance literature:: [[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-(2-methoxy-ethyl)-amino]-acetic acid ethyl ester; With lithium hydroxide monohydrate; In tetrahydrofuran; water; acetonitrile; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

: 540-38-5
p-Iodophenol

: 1299490-22-4
[[5-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d] isoxazol-3-yl]-(2-methoxy-ethyl)-amino]-acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1 h / 80 - 85 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide; tetrahydrofuran

3.1: hydrazine hydrate / ethanol / 3.5 h

4.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.08 h / Inert atmosphere

4.2: 80 °C / Inert atmosphere; sealed tube

5.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

6.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 11.5 h / 100 °C / Inert atmosphere; sealed tube

7.1: lithium hydroxide monohydrate / acetonitrile; water; tetrahydrofuran / 20 °C

With lithium hydroxide monohydrate; potassium carbonate; hydrazine hydrate; trifluoroacetic acid; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 64113-84-4
2-fluoro-5-methylbenzonitrile

: 1299490-22-4
[[5-(4',5'-Difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d] isoxazol-3-yl]-(2-methoxy-ethyl)-amino]-acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium tert-butylate / tetrahydrofuran / 20 °C / Reflux

1.2: 2 h / Reflux

1.3: pH 12

2.1: dmap / dichloromethane / 20 °C

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide; tetrahydrofuran

5.1: hydrazine hydrate / ethanol / 3.5 h

6.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.08 h / Inert atmosphere

6.2: 80 °C / Inert atmosphere; sealed tube

7.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

8.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 11.5 h / 100 °C / Inert atmosphere; sealed tube

9.1: lithium hydroxide monohydrate / acetonitrile; water; tetrahydrofuran / 20 °C

With N-Bromosuccinimide; lithium hydroxide monohydrate; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; potassium carbonate; hydrazine hydrate; trifluoroacetic acid; lithium hexamethyldisilazane; dmap; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;