[[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-(2-methoxy-ethyl)-amino]-acetic acid ethyl ester

Base Information

Chemical Name:[[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-(2-methoxy-ethyl)-amino]-acetic acid ethyl ester
CAS No.:1299490-29-1
Molecular Formula:C₂₈H₂₈F₂N₂O₆
Molecular Weight:526.537
Hs Code.:

Synonyms:[[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-(2-methoxy-ethyl)-amino]-acetic acid ethyl ester

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Chemical Property of [[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-(2-methoxy-ethyl)-amino]-acetic acid ethyl ester

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Technology Process of [[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-(2-methoxy-ethyl)-amino]-acetic acid ethyl ester

There total 11 articles about [[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-(2-methoxy-ethyl)-amino]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1299490-26-8
[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-(2-methoxy-ethyl)-amine

: 105-36-2
ethyl bromoacetate

: 1299490-29-1
[[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-(2-methoxy-ethyl)-amino]-acetic acid ethyl ester

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at 100 ℃; for 11.5h; Inert atmosphere; sealed tube;

Reference yield:

: 540-38-5
p-Iodophenol

: 1299490-29-1
[[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-(2-methoxy-ethyl)-amino]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1 h / 80 - 85 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide; tetrahydrofuran

3.1: hydrazine hydrate / ethanol / 3.5 h

4.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.08 h / Inert atmosphere

4.2: 80 °C / Inert atmosphere; sealed tube

5.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

6.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 11.5 h / 100 °C / Inert atmosphere; sealed tube

With potassium carbonate; hydrazine hydrate; trifluoroacetic acid; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 64113-84-4
2-fluoro-5-methylbenzonitrile

: 1299490-29-1
[[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-(2-methoxy-ethyl)-amino]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium tert-butylate / tetrahydrofuran / 20 °C / Reflux

1.2: 2 h / Reflux

1.3: pH 12

2.1: dmap / dichloromethane / 20 °C

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide; tetrahydrofuran

5.1: hydrazine hydrate / ethanol / 3.5 h

6.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.08 h / Inert atmosphere

6.2: 80 °C / Inert atmosphere; sealed tube

7.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

8.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 11.5 h / 100 °C / Inert atmosphere; sealed tube

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; potassium carbonate; hydrazine hydrate; trifluoroacetic acid; lithium hexamethyldisilazane; dmap; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide;