[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-(2-methoxy-ethyl)-amine

Base Information

Chemical Name:[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-(2-methoxy-ethyl)-amine
CAS No.:1299490-26-8
Molecular Formula:C₂₄H₂₂F₂N₂O₄
Molecular Weight:440.446
Hs Code.:

Synonyms:[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-(2-methoxy-ethyl)-amine

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Chemical Property of [5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-(2-methoxy-ethyl)-amine

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Technology Process of [5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-(2-methoxy-ethyl)-amine

There total 10 articles about [5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-(2-methoxy-ethyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1299490-25-7
[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-(2-methoxy-ethyl)-carbamic acid tert-butyl ester

: 1299490-26-8
[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-(2-methoxy-ethyl)-amine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2.5h;

Reference yield:

: 540-38-5
p-Iodophenol

: 1299490-26-8
[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-(2-methoxy-ethyl)-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1 h / 80 - 85 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide; tetrahydrofuran

3.1: hydrazine hydrate / ethanol / 3.5 h

4.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.08 h / Inert atmosphere

4.2: 80 °C / Inert atmosphere; sealed tube

5.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

With potassium carbonate; hydrazine hydrate; trifluoroacetic acid; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 64113-84-4
2-fluoro-5-methylbenzonitrile

: 1299490-26-8
[5-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzo[d]isoxazol-3-yl]-(2-methoxy-ethyl)-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate / tetrahydrofuran / 20 °C / Reflux

1.2: 2 h / Reflux

1.3: pH 12

2.1: dmap / dichloromethane / 20 °C

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide; tetrahydrofuran

5.1: hydrazine hydrate / ethanol / 3.5 h

6.1: lithium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 0.08 h / Inert atmosphere

6.2: 80 °C / Inert atmosphere; sealed tube

7.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; potassium carbonate; hydrazine hydrate; trifluoroacetic acid; lithium hexamethyldisilazane; dmap; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide;