4-chloro-6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidine

Base Information

Chemical Name:4-chloro-6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidine
CAS No.:1258604-32-8
Molecular Formula:C₁₆H₁₆ClN₃O₅
Molecular Weight:365.773
Hs Code.:

Synonyms:4-chloro-6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidine

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Chemical Property of 4-chloro-6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidine

Chemical Property:

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Technology Process of 4-chloro-6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidine

There total 5 articles about 4-chloro-6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4316-93-2
4,6-dichloro-5-nitropyrimidine

: 1258604-31-7
4-(2,2-dimethyl-1,3-dioxan-5-yl)phenol

: 1258604-32-8
4-chloro-6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidine

Guidance literature:: With potassium carbonate; In ISOPROPYLAMIDE; at -20 - -10 ℃;

Reference yield:

: 56441-69-1
2-<4-(phenylmethoxy)phenyl>acetic acid ethyl ester

: 1258604-32-8
4-chloro-6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / THF (tetrahydrofuran) / 19 h / 0 - 30 °C

2.1: sodium tetrahydroborate / ethanol / 4 h / 0 - 30 °C

2.2: Cooling with ice

3.1: toluene-4-sulfonic acid / toluene / 18 h / 30 °C

4.1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Reflux

5.1: potassium carbonate / ISOPROPYLAMIDE / 2 h / -20 - -10 °C

With sodium tetrahydroborate; ammonium formate; sodium hydride; potassium carbonate; palladium 10% on activated carbon; toluene-4-sulfonic acid; In methanol; ethanol; ISOPROPYLAMIDE; toluene;

Reference yield:

: 24220-48-2
diethyl 2-(4'-benzyloxyphenyl)malonate

: 1258604-32-8
4-chloro-6-(4-(2,2-dimethyl-1,3-dioxan-5-yl)phenoxy)-5-nitropyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / ethanol / 4 h / 0 - 30 °C

1.2: Cooling with ice

2.1: toluene-4-sulfonic acid / toluene / 18 h / 30 °C

3.1: ammonium formate / palladium 10% on activated carbon / methanol / 2 h / Reflux

4.1: potassium carbonate / ISOPROPYLAMIDE / 2 h / -20 - -10 °C

With sodium tetrahydroborate; ammonium formate; potassium carbonate; palladium 10% on activated carbon; toluene-4-sulfonic acid; In methanol; ethanol; ISOPROPYLAMIDE; toluene;