ethyl 1-benzyl-4-methyl-1,8-naphthyridin-(1H)2-one-3-carboxylate

Base Information

• Chemical Name: ethyl 1-benzyl-4-methyl-1,8-naphthyridin-(1H)2-one-3-carboxylate
• CAS No.: 161987-61-7
• Molecular Formula: C₁₉H₁₈N₂O₃
• Molecular Weight: 322.364
• Mol file: 161987-61-7.mol

Synonyms:ethyl 1-benzyl-4-methyl-1,8-naphthyridin-(1H)2-one-3-carboxylate

Chemical Property of ethyl 1-benzyl-4-methyl-1,8-naphthyridin-(1H)2-one-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 1-benzyl-4-methyl-1,8-naphthyridin-(1H)2-one-3-carboxylate

There total 4 articles about ethyl 1-benzyl-4-methyl-1,8-naphthyridin-(1H)2-one-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

benzyl bromide (100-39-0) + ethyl 4-methyl-1,8-naphthyridin-(1H)2-one-3-carboxylate (161987-60-6) → ethyl 1-benzyl-4-methyl-1,8-naphthyridin-(1H)2-one-3-carboxylate (161987-61-7)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

DOI:10.1016/0040-4020(94)00922-H

Reference yield:

2-(pivaloylamino)pyridine (86847-59-8) → ethyl 1-benzyl-4-methyl-1,8-naphthyridin-(1H)2-one-3-carboxylate (161987-61-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 60 percent / 1.6 M n-butyl lithium in hexane / tetrahydrofuran / 1 h / -40 °C

2: 100 percent / 3 N aqueous hydrochloric acid / 14 h / Heating

3: 63 percent / potassium hydroxide / 14 h / 110 °C

4: 74 percent / sodium hydride / dimethylformamide / 1 h / 0 °C

With hydrogenchloride; potassium hydroxide; n-butyllithium; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/0040-4020(94)00922-H

Reference yield:

1-(2-amino-3-pyridinyl)-1-ethanone (65326-33-2) → ethyl 1-benzyl-4-methyl-1,8-naphthyridin-(1H)2-one-3-carboxylate (161987-61-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / potassium hydroxide / 14 h / 110 °C

2: 74 percent / sodium hydride / dimethylformamide / 1 h / 0 °C

With potassium hydroxide; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1016/0040-4020(94)00922-H

upstream raw materials:

benzyl bromide

ethyl 4-methyl-1,8-naphthyridin-(1H)2-one-3-carboxylate

2-(pivaloylamino)pyridine

1-(2-amino-3-pyridinyl)-1-ethanone

Downstream raw materials:

1-benzyl-4-methyl-1,8-naphthyridin-(1H)2-one-3-carboxylic acid

2-bromoethyl 1-benzyl-4-methyl-1,8-naphthyridin-(1H)2-one-3-carboxylate