(Methyl-{1-[4-(2-methyl-benzoylamino)-benzoyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl}-amino)-acetic acid ethyl ester

Base Information

Chemical Name:(Methyl-{1-[4-(2-methyl-benzoylamino)-benzoyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl}-amino)-acetic acid ethyl ester
CAS No.:150681-95-1
Molecular Formula:C₃₀H₃₃N₃O₄
Molecular Weight:499.61
Hs Code.:

Synonyms:(Methyl-{1-[4-(2-methyl-benzoylamino)-benzoyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl}-amino)-acetic acid ethyl ester

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Chemical Property of (Methyl-{1-[4-(2-methyl-benzoylamino)-benzoyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl}-amino)-acetic acid ethyl ester

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Technology Process of (Methyl-{1-[4-(2-methyl-benzoylamino)-benzoyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl}-amino)-acetic acid ethyl ester

There total 6 articles about (Methyl-{1-[4-(2-methyl-benzoylamino)-benzoyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl}-amino)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 105-36-2
ethyl bromoacetate

: 154890-02-5
5-methylamino-1-[4-[(2-methylbenzoyl)amino]benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine

: 150681-95-1
(Methyl-{1-[4-(2-methyl-benzoylamino)-benzoyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl}-amino)-acetic acid ethyl ester

Guidance literature:: With potassium carbonate; In acetonitrile; for 3h; Heating;
DOI:10.1021/jm960133o

Reference yield:

: 1127-74-8
1,2,3,4-tetrahydro-5H-benzo[b] azepin-5-one

: 150681-95-1
(Methyl-{1-[4-(2-methyl-benzoylamino)-benzoyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl}-amino)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

2: H₂ / 10percent Pd/C / ethanol / 5 h / 760 Torr / Ambient temperature

3: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

4: 1.) molecular sieves 4A, 2.) NaBH₄ / 1.) CH₃OH, DMF, reflux, 5 h, 2.) CH₃OH, THF, RT, 1 h

5: 41 percent / K₂CO₃ / acetonitrile / 3 h / Heating

With sodium tetrahydroborate; 4 A molecular sieve; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jm960133o

Reference yield:

: 122-04-3
4-nitro-benzoyl chloride

: 150681-95-1
(Methyl-{1-[4-(2-methyl-benzoylamino)-benzoyl]-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl}-amino)-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

2: H₂ / 10percent Pd/C / ethanol / 5 h / 760 Torr / Ambient temperature

3: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

4: 1.) molecular sieves 4A, 2.) NaBH₄ / 1.) CH₃OH, DMF, reflux, 5 h, 2.) CH₃OH, THF, RT, 1 h

5: 41 percent / K₂CO₃ / acetonitrile / 3 h / Heating

With sodium tetrahydroborate; 4 A molecular sieve; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jm960133o